8u0b: Difference between revisions
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New page: '''Unreleased structure''' The entry 8u0b is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Crystal structure of Lyssavirus rabies (Nishigahara strain) nucleoprotein in complex with phosphomimetic phosphoprotein S48E== | |||
<StructureSection load='8u0b' size='340' side='right'caption='[[8u0b]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8u0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U0B FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u0b OCA], [https://pdbe.org/8u0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u0b RCSB], [https://www.ebi.ac.uk/pdbsum/8u0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u0b ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/B9VMI2_9RHAB B9VMI2_9RHAB] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus.[RuleBase:RU004918][https://www.uniprot.org/uniprot/Q5NU29_9RHAB Q5NU29_9RHAB] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rabies lyssavirus]] | |||
[[Category: Donnelly CM]] | |||
[[Category: Forwood JK]] | |||
[[Category: Stewart M]] | |||
Latest revision as of 05:15, 23 April 2025
Crystal structure of Lyssavirus rabies (Nishigahara strain) nucleoprotein in complex with phosphomimetic phosphoprotein S48E
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