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[[Image:1odz.gif|left|200px]]
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{{STRUCTURE_1odz|  PDB=1odz  |  SCENE=  }}
'''EXPANSION OF THE GLYCOSYNTHASE REPERTOIRE TO PRODUCE DEFINED MANNO-OLIGOSACCHARIDES'''


==Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides==
<StructureSection load='1odz' size='340' side='right'caption='[[1odz]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1odz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ODZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1odz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1odz OCA], [https://pdbe.org/1odz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1odz RCSB], [https://www.ebi.ac.uk/pdbsum/1odz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1odz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MANA_CELJU MANA_CELJU] Hydrolyzes mannan and galactomannan, but displays little activity towards other polysaccharides located in the plant cell wall. Appears to act in synergy with alpha-galactosidase (AgaA) to elicit hydrolysis of galactomannan. Preferentially hydrolyzes the larger oligosaccharides and has greater activity against non-substituted polysaccharides.<ref>PMID:7848261</ref> <ref>PMID:11064195</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/1odz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1odz ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mutant endo-mannanases, in which the catalytic nucleophile has been replaced, function as glycosynthases in the synthesis of manno-oligosaccharides of defined lengths.


==Overview==
Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides.,Jahn M, Stoll D, Warren RA, Szabo L, Singh P, Gilbert HJ, Ducros VM, Davies GJ, Withers SG Chem Commun (Camb). 2003 Jun 21;(12):1327-9. PMID:12841226<ref>PMID:12841226</ref>
Mutant endo-mannanases, in which the catalytic nucleophile has been replaced, function as glycosynthases in the synthesis of manno-oligosaccharides of defined lengths.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1ODZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODZ OCA].
</div>
<div class="pdbe-citations 1odz" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides., Jahn M, Stoll D, Warren RA, Szabo L, Singh P, Gilbert HJ, Ducros VM, Davies GJ, Withers SG, Chem Commun (Camb). 2003 Jun 21;(12):1327-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12841226 12841226]
*[[Mannosidase 3D structures|Mannosidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cellvibrio japonicus]]
[[Category: Cellvibrio japonicus]]
[[Category: Mannan endo-1,4-beta-mannosidase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Davies GJ]]
[[Category: Davies, G J.]]
[[Category: Ducros VMA]]
[[Category: Ducros, V M.A.]]
[[Category: Gilbert HJ]]
[[Category: Gilbert, H J.]]
[[Category: Jahn M]]
[[Category: Jahn, M.]]
[[Category: Singh P]]
[[Category: Singh, P.]]
[[Category: Stoll D]]
[[Category: Stoll, D.]]
[[Category: Szabo L]]
[[Category: Szabo, L.]]
[[Category: Warren RAJ]]
[[Category: Warren, R A.J.]]
[[Category: Withers SG]]
[[Category: Withers, S G.]]
[[Category: Family 26]]
[[Category: Glycoside-hydrolase]]
[[Category: Glycosynthase]]
[[Category: Mannanase]]
[[Category: Manno-oligosaccharide]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:43:30 2008''

Latest revision as of 12:37, 13 December 2023

Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides

1odz, resolution 1.40Å

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