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New page: left|200px<br /> <applet load="1oks" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oks, resolution 1.80Å" /> '''CRYSTAL STRUCTURE O...
 
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[[Image:1oks.gif|left|200px]]<br />
<applet load="1oks" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1oks, resolution 1.80&Aring;" />
'''CRYSTAL STRUCTURE OF THE MEASLES VIRUS PHOSPHOPROTEIN XD DOMAIN'''<br />


==Overview==
==Crystal structure of the measles virus phosphoprotein XD domain==
Measles virus is a negative-sense, single-stranded RNA virus belonging to, the Mononegavirales order which comprises several human pathogens such as, Ebola, Nipah, and Hendra viruses. The phosphoprotein of measles virus is a, modular protein consisting of an intrinsically disordered N-terminal, domain (Karlin, D., Longhi, S., Receveur, V., and Canard, B. (2002), Virology 296, 251-262) and of a C-terminal moiety (PCT) composed of, alternating disordered and globular regions. We report the crystal, structure of the extreme C-terminal domain (XD) of measles virus, phosphoprotein (aa 459-507) at 1.8 A resolution. We have previously, reported that the C-terminal domain of measles virus nucleoprotein, NTAIL, is intrinsically unstructured and undergoes induced folding in the, presence of PCT ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12944395 (full description)]]
<StructureSection load='1oks' size='340' side='right'caption='[[1oks]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1oks]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OKS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oks OCA], [https://pdbe.org/1oks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oks RCSB], [https://www.ebi.ac.uk/pdbsum/1oks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oks ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHOSP_MEASE PHOSP_MEASE] Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/1oks_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oks ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1OKS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Measles_virus Measles virus]] with NHE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKS OCA]].
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of the measles virus phosphoprotein domain responsible for the induced folding of the C-terminal domain of the nucleoprotein., Johansson K, Bourhis JM, Campanacci V, Cambillau C, Canard B, Longhi S, J Biol Chem. 2003 Nov 7;278(45):44567-73. Epub 2003 Aug 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12944395 12944395]
[[Category: Large Structures]]
[[Category: Measles virus]]
[[Category: Measles morbillivirus]]
[[Category: Single protein]]
[[Category: Bourhis J-M]]
[[Category: Bourhis, J.M.]]
[[Category: Cambillau C]]
[[Category: Cambillau, C.]]
[[Category: Campanacci V]]
[[Category: Campanacci, V.]]
[[Category: Canard B]]
[[Category: Canard, B.]]
[[Category: Johansson K]]
[[Category: Johansson, K.]]
[[Category: Longhi S]]
[[Category: Longhi, S.]]
[[Category: NHE]]
[[Category: nucleocapsid]]
[[Category: phosphorylation.]]
[[Category: rna-directed rna polymerase]]
[[Category: transferase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 18:25:15 2007''

Latest revision as of 05:48, 17 April 2024

Crystal structure of the measles virus phosphoprotein XD domain

1oks, resolution 1.80Å

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