8x62: Difference between revisions

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'''Unreleased structure'''


The entry 8x62 is ON HOLD  until Paper Publication
==crystal structure of human Mcl-1 kinase domain in complex with RM1==
 
<StructureSection load='8x62' size='340' side='right'caption='[[8x62]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors: Zhang, Z.M., Wang, L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8x62]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X62 FirstGlance]. <br>
Description: crystal structure of human Mcl-1 kinase domain in complex with RM1
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8033946&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YO0:1-[7-[1,5-dimethyl-3-(phenoxymethyl)pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indol-2-yl]-2,2-bis(oxidanyl)ethanone'>YO0</scene></td></tr>
[[Category: Zhang, Z.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x62 OCA], [https://pdbe.org/8x62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x62 RCSB], [https://www.ebi.ac.uk/pdbsum/8x62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x62 ProSAT]</span></td></tr>
[[Category: Wang, L]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang L]]
[[Category: Zhang ZM]]
Retrieved from "https://proteopedia.org/8x62"