8zwc: Difference between revisions

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'''Unreleased structure'''


The entry 8zwc is ON HOLD
==Cryo-EM Structure of the BLOC-3 complex==
 
<StructureSection load='8zwc' size='340' side='right'caption='[[8zwc]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8zwc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZWC FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.19&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zwc OCA], [https://pdbe.org/8zwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zwc RCSB], [https://www.ebi.ac.uk/pdbsum/8zwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zwc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HPS1_HUMAN HPS1_HUMAN] Hermansky-Pudlak syndrome due to BLOC-3 deficiency. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/HPS1_HUMAN HPS1_HUMAN] Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).<ref>PMID:23084991</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jia D]]
[[Category: Jia GW]]
[[Category: Su ZM]]
[[Category: Yong X]]
Retrieved from "https://proteopedia.org/8zwc"