Fibroblast growth factor: Difference between revisions

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'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development.  FGF is heparin-binding protein.  FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR).  In vertebrates there are 23 members in the FGF family<ref>PMID:11276432</ref>. <br />
'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development.  FGF is heparin-binding protein.  FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR).  In vertebrates there are 23 members in the FGF family<ref>PMID:11276432</ref>. <br />
*  '''FGF1''' is called acidic FGF.<br />
*  '''FGF1''' is called acidic FGF.<br />
*  '''FGF2''' is called basic FGF.<br />
*  '''FGF2''' is called basic FGF.  See also [[API5-FGF2 complex]].<br />
*  '''FGF4''' has multiple roles during vertebrate embryogenesis<ref>PMID:18792115</ref>.<br />
*  '''FGF4''' has multiple roles during vertebrate embryogenesis<ref>PMID:18792115</ref>.<br />
*  '''FGF7''' is called '''keratinocyte growth factor''' which is present in the epitheliazation-phase of wound healing when keratinocytes are covering the wound<ref>PMID:11052999</ref>.  FGF7 is aparacrine growth factor in the breast<ref>PMID:12697038</ref>.
*  '''FGF7''' is called '''keratinocyte growth factor''' which is present in the epitheliazation-phase of wound healing when keratinocytes are covering the wound<ref>PMID:11052999</ref>.  FGF7 is aparacrine growth factor in the breast<ref>PMID:12697038</ref>.
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*  '''FGF13''' regulates proliferation and differentiation of the skeletal muscle cells <ref>PMID:26230950</ref>.<br />
*  '''FGF13''' regulates proliferation and differentiation of the skeletal muscle cells <ref>PMID:26230950</ref>.<br />
*  '''FGF18''' has al role in organ development and damage repair <ref>PMID:36871047</ref>.<br />
*  '''FGF18''' has al role in organ development and damage repair <ref>PMID:36871047</ref>.<br />
*  '''FGF19''' has high affinity to FGFR4<ref>PMID:10525310</ref>.<br />
*  '''FGF21''' has a role in regulating body weight in a dietary carbohydrate-dependent manner <ref>PMID:37030441</ref>.<br />
*  '''FGF23''' is produced by bone cells and regulates renal phosphate and vitamin D metabolism <ref>PMID:29760049</ref>.<br />
*  '''FGF23''' is produced by bone cells and regulates renal phosphate and vitamin D metabolism <ref>PMID:29760049</ref>.<br />
See also [[Fibroblast growth factor receptor]] and [[Growth factors]].
See also [[Fibroblast growth factor receptor]] and [[Growth factors]].

Latest revision as of 07:24, 12 July 2026

Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code 2uus)

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References

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Michal Harel, Alexander Berchansky

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