9n8y: Difference between revisions
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New page: '''Unreleased structure''' The entry 9n8y is ON HOLD Authors: Marx, D.C., Levitz, J.T. Description: Cryo EM Structure of Full Length mGluR8 Bound to Agonist L-AP4 and PAM VU6005649 [[C... |
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==Cryo EM Structure of Full Length mGluR8 Bound to Agonist L-AP4 and PAM VU6005649== | |||
<StructureSection load='9n8y' size='340' side='right'caption='[[9n8y]], [[Resolution|resolution]] 2.76Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9n8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9N8Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.76Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BWG:3-[2,3-bis(fluoranyl)-4-methoxy-phenyl]-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine'>A1BWG</scene>, <scene name='pdbligand=E7P:(2S)-2-amino-4-phosphonobutanoic+acid'>E7P</scene></td></tr> | ||
[[Category: Levitz | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n8y OCA], [https://pdbe.org/9n8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n8y RCSB], [https://www.ebi.ac.uk/pdbsum/9n8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n8y ProSAT]</span></td></tr> | ||
[[Category: Marx | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Levitz JT]] | |||
[[Category: Marx DC]] | |||
Latest revision as of 10:49, 30 September 2026
Cryo EM Structure of Full Length mGluR8 Bound to Agonist L-AP4 and PAM VU6005649
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