9up5: Difference between revisions
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New page: '''Unreleased structure''' The entry 9up5 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Crystal structure of LapB from Klebsiella pneumoniae== | |||
<StructureSection load='9up5' size='340' side='right'caption='[[9up5]], [[Resolution|resolution]] 3.44Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9up5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UP5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.44Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9up5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9up5 OCA], [https://pdbe.org/9up5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9up5 RCSB], [https://www.ebi.ac.uk/pdbsum/9up5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9up5 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
LabB (YciM) is a key regulator of lipopolysaccharide (LPS) biosynthesis in Gram-negative bacteria, modulating LpxC degradation to maintain outer membrane integrity. While E. coli LabB (ecLabB) forms a closed-ring dimer via TPR motifs, the crystal structure of Klebsiella pneumoniae LabB (kpLabB) reveals a distinct open-ring dimeric architecture, generated by TPR motif sliding. This alternative conformation suggests a potential mechanism for dynamic regulation and partner interactions. | |||
Structural analysis of LabB from Klebsiella pneumoniae reveals an alternative dimeric conformation generated by the sliding of TPR motifs.,Jung KH, Lee SY, Park SE, Kang YW, Park HH Biochem Biophys Res Commun. 2025 Aug 15;775:152151. doi: , 10.1016/j.bbrc.2025.152151. Epub 2025 Jun 3. PMID:40480088<ref>PMID:40480088</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 9up5" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Klebsiella pneumoniae]] | |||
[[Category: Large Structures]] | |||
[[Category: Jung KH]] | |||
[[Category: Lee SY]] | |||
[[Category: Park HH]] | |||
Latest revision as of 07:58, 4 March 2026
Crystal structure of LapB from Klebsiella pneumoniae
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