Hydroxysteroid dehydrogenase 3D structures: Difference between revisions

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*3-α HSD or AKR1C2

**[[1ral]] – rHSD – rat<BR />

**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />

**[[7p36]], [[8kc6]] - LkHSD – ''Lactobacillus kefiri''<br />

**[[8kcn]] - LkHSD (mutant)<br />

*''3-α HSD binary complex''

**[[2fvl]], [[2hdj]] - hHSD + NADP - human<BR />

**[[1lwi]] – rHSD + NADP<BR />

**[[4is3]] - CsHSD + NAD<br />

**[[7ejh]], [[7eji]], [[7ejj]], [[7vdo]], [[7vet]] - LkHSD (mutant`) + NADP <br />

*''3-α HSD ternary complex''

**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP <br />

**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />

*3-α HSD type 3

**[[2hdj]] - hHSD + NADP<br />

**[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP <br />

**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />

**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br />

*7-α HSD  

**[[3gaf]] - BmHSD – ''Brucella melitensis''<BR />

**[[8hax]], [[8hde]], [[8hdi]], [[8hdn]], [[8hs6]], [[8hs9]] - BmHSD (mutant)<BR />

**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD<br />

**[[5epo]] – HSD + NADP – ''Clostridium sardiniese''<br />

*7-beta HSD   

**[[5fyd]] – CaHSD – ''Collinsella aerofaciens<''br />

**[[5gt9]] – CaHSD + NADP<br />

*20-α HSD or AKR1C1  

**[[6a7a]], [[8jp2]] – hHSD + NADP + inhibitor<br />

**[[1q5m]] - raHSD + NADP – rabbit

*''20-α HSD  ternary complex''

**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />

**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br />

**[[6ijx]] – hHSD + NADP + meclofenamic acid<br />

**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />

*20-beta HSD   

**[[6m9u]] – BaHSD – ''Bifidobacterium adolescentis''<br />

**[[6ow4]] – BaHSD + NADP <br />

*11-β HSD or corticosteroid  11-β-dehydrogenase 1

**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />

**[[2pd6]] - hHSD + NAD<BR />

**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />

**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />

*''11-β HSD  ternary complex''

**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />

**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]], [[4yyz]]  - hHSD 1 + inhibitor + NADP<BR />

**[[4k26]], [[5qij]] - mHSD 1 + inhibitor + NADP<br />

**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />

*17-α HSD or AKR1C21

**[[2he8]] – mHSD - mouse <br />

**[[3fjn]] - mHSD (mutant) <br />

**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />

**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />

*17-β HSD or estradiol 11-β-dehydrogenase 1

**[[1bhs]] – hHSD 1 <BR />

**[[1s9c]] - hHSD 4 (mutant) <BR />

**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />

**[[3itd]] - ClHSD (mutant)

*''17-β HSD binary complex''

**[[1fds]], [[1iol]], [[1jtv]], [[1yb1]], [[3dhe]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br />

**[[1dht]], [[1fdw]] - hHSD (mutant) + hydroxysteroid<BR />

**[[3qwf]] - ClHSD + NADP<BR />

**[[4fiz]], [[4fj0]], [[4fj1]], [[4fj2]] – ClHSD + dehydroxy flavonoid inhibitor<br />

*''17-β HSD ternary complex''

**[[1fdt]], [[1qyw]], [[1qyx]] - hHSD 1 + hydroxysteroid + NADP<BR />

**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />

**[[5hs6]] - hHSD 14 + NAD + estrone<br />

**[[3qwh]], [[3qwi]] - ClHSD + hydroxysteroid + NADP<BR />

*3-α 20-β HSD

**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />

**[[1hdc]] – SeHSD + inhibitor

*Carbonyl reductase/20-β HSD

**[[1n5d]]  - HSD + NADP – pig<br />

*3-β/17-β HSD

**[[1hxh ]] - CtHSD

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