29wa: Difference between revisions
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==Structure of Cannabidiolic acid synthase(CBDAS) in complex with FAD== | |||
<StructureSection load='29wa' size='340' side='right'caption='[[29wa]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[29wa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cannabis_sativa Cannabis sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=29WA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=29WA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=29wa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=29wa OCA], [https://pdbe.org/29wa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=29wa RCSB], [https://www.ebi.ac.uk/pdbsum/29wa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=29wa ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CBDAS_CANSA CBDAS_CANSA] Oxidoreductase involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity (PubMed:17544411, PubMed:8663284). Catalyzes the stereoselective oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA), producing cannabidiolate (CBDA), the major cannabioid in fiber-type Cannabis plants (PubMed:17544411, PubMed:8663284). Can also use cannabinerolic acid as substrate, but not cannabigerol or cannabinerol (PubMed:17544411, PubMed:8663284).<ref>PMID:17544411</ref> <ref>PMID:8663284</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cannabis sativa]] | |||
[[Category: Large Structures]] | |||
[[Category: Cartwright J]] | |||
[[Category: Domenech J]] | |||
[[Category: Grogan G]] | |||
Latest revision as of 19:56, 29 July 2026
Structure of Cannabidiolic acid synthase(CBDAS) in complex with FAD
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