29km: Difference between revisions

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'''Unreleased structure'''


The entry 29km is ON HOLD  until Paper Publication
==Cryo-EM structure of Bacillus subtilis DnaB==
 
<StructureSection load='29km' size='340' side='right'caption='[[29km]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors: Campoy, R.R., Guyet, A., Pelliciari, S., Murray, H., Ilangovan, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[29km]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=29KM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=29KM FirstGlance]. <br>
Description: Cryo-EM structure of Bacillus subtilis DnaB
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=29km FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=29km OCA], [https://pdbe.org/29km PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=29km RCSB], [https://www.ebi.ac.uk/pdbsum/29km PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=29km ProSAT]</span></td></tr>
[[Category: Guyet, A]]
</table>
[[Category: Campoy, R.R]]
== Function ==
[[Category: Murray, H]]
[https://www.uniprot.org/uniprot/DNAB_BACSU DNAB_BACSU] Helps DnaI load the DnaC replicative helicase onto single-stranded (ss)DNA (PubMed:12718886). During DNA replication from the origin of replication (oriC) in the DNA replisome, DnaD is required after DnaA, before DnaB and before subsequent helicase DnaC loading (PubMed:15186423, PubMed:19968790). Component of the replication restart primosome, which reloads the replicative helicase on sites other than oriC (PubMed:11585815). DnaB, DnaD and DnaI may also be required for a PriA-independent pathway of replication fork restart (PubMed:11679082). DnaB and DnaD work together to allow DnaB access to ssDNA (PubMed:15686560). DNA replication at oriC might originate on the inner face of the cell membrane; DnaB is essential for both replication initiation and cell membrane attachment of the origin region of the chromosome and plasmids (PubMed:6771760, PubMed:3027671, PubMed:3027697). Weakly binds ssDNA (PubMed:11585815, PubMed:15686560, PubMed:32817095), preferentially binds double-stranded (ds)DNA (PubMed:32817095), and replication fork-like substrates (PubMed:11585815). Remodels DNA, laterally compacts supercoiled plasmid and linear DNA, forms beads along the dsDNA (PubMed:16002087). Together DnaB and DnaD form bipolar complexes on plasmid DNA (PubMed:16002087). DnaB and DnaD are also required to load helicase on the repN plasmid origin of replication (oriN) (PubMed:36416272).<ref>PMID:11679082</ref> <ref>PMID:12718886</ref> <ref>PMID:15186423</ref> <ref>PMID:16002087</ref> <ref>PMID:19968790</ref> <ref>PMID:3027671</ref> <ref>PMID:3027697</ref> <ref>PMID:32817095</ref> <ref>PMID:36416272</ref> <ref>PMID:6771760</ref>
[[Category: Ilangovan, A]]
== References ==
[[Category: Pelliciari, S]]
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Campoy RR]]
[[Category: Guyet A]]
[[Category: Ilangovan A]]
[[Category: Murray H]]
[[Category: Pelliciari S]]
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