9sau: Difference between revisions
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==Chlorophyll synthase in complex with the LHC-like protein HliD, GGPP-bound state== | |||
<StructureSection load='9sau' size='340' side='right'caption='[[9sau]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9sau]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SAU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5X6:(1~{R})-3,5,5-trimethyl-4-[(1~{E},3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E})-3,7,12,16-tetramethyl-18-[(4~{R})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol'>5X6</scene>, <scene name='pdbligand=A1JR2:(2~{S},3~{R},4~{R},5~{R},6~{S})-2-[(3~{R},4~{E},6~{E},8~{E},10~{E},12~{E},14~{E},16~{E},18~{E},20~{E},22~{E},24~{E})-2,6,10,14,19,23-hexamethyl-2-oxidanyl-25-[(4~{S})-2,2,6-trimethyl-4-oxidanyl-cyclohexyl]pentacosa-4,6,8,10,12,14,16,18,20,22,24-undecaen-3-yl]oxy-6-methyl-oxane-3,4,5-triol'>A1JR2</scene>, <scene name='pdbligand=CLA:CHLOROPHYLL+A'>CLA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=MGE:(1S)-2-(ALPHA-L-ALLOPYRANOSYLOXY)-1-[(TRIDECANOYLOXY)METHYL]ETHYL+PALMITATE'>MGE</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sau OCA], [https://pdbe.org/9sau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sau RCSB], [https://www.ebi.ac.uk/pdbsum/9sau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sau ProSAT]</span></td></tr> | ||
[[Category: Hitchcock | </table> | ||
[[Category: Sobotka | == Function == | ||
[https://www.uniprot.org/uniprot/HLID_SYNY3 HLID_SYNY3] Involved in photosystem II (PSII) assembly and/or repair under high light stress (PubMed:24681620). Required for binding of chlorophyll and carotenoids by the Ycf39-Hlip complex. The Ycf39-Hlip complex binds D1 at an early stage of PSII assembly along with Ycf48, ribosomes and ChlG, the last enzyme in chlorophyll biosynthesis; it may be involved in chlorophyll reuse and delivery to D1 in the initial stages of PSII assembly (PubMed:24681620). Binds chlorophyll a and beta-carotenoid in a 3:1 stoichiometry in the presence and absence of Yfc39; in the Ycf39-HliC-HliD complex, HliD binds all the pigment. The Ycf39-Hlip complex efficiently quenches chlorophyll fluorescence, contributing to photoprotection (PubMed:25706339). Deletion of 4 to 5 members of the Hlip family suggests the proteins are involved in regulation of chlorophyll biosynthesis, in stabilization of chlorophyll-binding proteins and/or in reuse of chlorophylls, and may regulate tetrapyrrole biosynthesis (Probable). Might bind chlorophyll and/or carotenoids in association with HliC (called the ScpBE pair) (Probable).<ref>PMID:24681620</ref> <ref>PMID:25706339</ref> <ref>PMID:15107425</ref> <ref>PMID:18836846</ref> The Hlips might regulate tetrapyrrole biosynthesis, maybe at the level of aminolevulinic acid synthesis and probably stabilize PSII assembly intermediates (PubMed:11999371, PubMed:22090028).<ref>PMID:11999371</ref> <ref>PMID:22090028</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synechocystis sp. PCC 6803]] | |||
[[Category: Hitchcock A]] | |||
[[Category: Shvarev D]] | |||
[[Category: Sobotka R]] | |||
Latest revision as of 05:03, 19 August 2026
Chlorophyll synthase in complex with the LHC-like protein HliD, GGPP-bound state
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