2dl1: Difference between revisions

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New page: left|200px<br /> <applet load="2dl1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dl1" /> '''Solution structure of the MIT domain from h...
 
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[[Image:2dl1.gif|left|200px]]<br />
<applet load="2dl1" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2dl1" />
'''Solution structure of the MIT domain from human Spartin'''<br />


==Disease==
==Solution structure of the MIT domain from human Spartin==
Known disease associated with this structure: Troyer syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607111 607111]]
<StructureSection load='2dl1' size='340' side='right'caption='[[2dl1]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2dl1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DL1 FirstGlance]. <br>
2DL1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DL1 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dl1 OCA], [https://pdbe.org/2dl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dl1 RCSB], [https://www.ebi.ac.uk/pdbsum/2dl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dl1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dl1 TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SPART_HUMAN SPART_HUMAN] Autosomal recessive spastic paraplegia type 20. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SPART_HUMAN SPART_HUMAN] May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964).<ref>PMID:20719964</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dl1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dl1 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Suetake T]]
[[Category: Suetake, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: mit]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: spartin]]
[[Category: spg20]]
[[Category: structural genomics]]
 
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