2e0t: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /> <applet load="2e0t" size="450" color="white" frame="true" align="right" spinBox="true" caption="2e0t, resolution 1.67Å" /> '''Crystal structure o... |
No edit summary |
||
| (16 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== | ==Crystal structure of catalytic domain of dual specificity phosphatase 26, MS0830 from Homo sapiens== | ||
<StructureSection load='2e0t' size='340' side='right'caption='[[2e0t]], [[Resolution|resolution]] 1.67Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2e0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E0T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e0t OCA], [https://pdbe.org/2e0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e0t RCSB], [https://www.ebi.ac.uk/pdbsum/2e0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e0t ProSAT], [https://www.topsan.org/Proteins/RSGI/2e0t TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DUS26_HUMAN DUS26_HUMAN] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).<ref>PMID:15796912</ref> <ref>PMID:16924234</ref> <ref>PMID:17001450</ref> <ref>PMID:16581800</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/2e0t_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e0t ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chen L]] | |||
[[Category: Chen | [[Category: Hori-Takemoto C]] | ||
[[Category: Hori-Takemoto | [[Category: Kishishita S]] | ||
[[Category: Kishishita | [[Category: Liu ZJ]] | ||
[[Category: Liu | [[Category: Murayama K]] | ||
[[Category: Murayama | [[Category: Shirozu M]] | ||
[[Category: Wang BC]] | |||
[[Category: Shirozu | [[Category: Xie Y]] | ||
[[Category: Wang | [[Category: Yokoyama S]] | ||
[[Category: Xie | |||
[[Category: Yokoyama | |||
Latest revision as of 13:48, 13 March 2024
Crystal structure of catalytic domain of dual specificity phosphatase 26, MS0830 from Homo sapiens
| ||||||||||||
