1bgw: Difference between revisions

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New page: left|200px<br /> <applet load="1bgw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bgw, resolution 2.7Å" /> '''TOPOISOMERASE RESIDU...
 
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[[Image:1bgw.gif|left|200px]]<br />
<applet load="1bgw" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1bgw, resolution 2.7&Aring;" />
'''TOPOISOMERASE RESIDUES 410-1202,'''<br />


==Overview==
==TOPOISOMERASE RESIDUES 410-1202,==
The crystal structure of a large fragment of yeast type II DNA, topoisomerase reveals a heart-shaped dimeric protein with a large central, hole. It provides a molecular model of the enzyme as an ATP-modulated, clamp with two sets of jaws at opposite ends, connected by multiple, joints. An enzyme with bound DNA can admit a second DNA duplex through one, set of jaws, transport it through the cleaved first duplex, and expel it, through the other set of jaws.
<StructureSection load='1bgw' size='340' side='right'caption='[[1bgw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The January 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Topoisomerases''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_1 10.2210/rcsb_pdb/mom_2006_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgw OCA], [https://pdbe.org/1bgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgw RCSB], [https://www.ebi.ac.uk/pdbsum/1bgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TOP2_YEAST TOP2_YEAST] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:9685374</ref> <ref>PMID:23022727</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/1bgw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bgw ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1BGW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1BGW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_1.html Topoisomerases]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BGW OCA].
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
 
== References ==
==Reference==
<references/>
Structure and mechanism of DNA topoisomerase II., Berger JM, Gamblin SJ, Harrison SC, Wang JC, Nature. 1996 Jan 18;379(6562):225-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8538787 8538787]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Topoisomerases]]
[[Category: Topoisomerases]]
[[Category: Berger, J.M.]]
[[Category: Berger JM]]
[[Category: Gamblin, S.J.]]
[[Category: Gamblin SJ]]
[[Category: Harrison, S.C.]]
[[Category: Harrison SC]]
[[Category: Wang, J.C.]]
[[Category: Wang JC]]
[[Category: dna-binding]]
[[Category: isomerase]]
[[Category: phosphorylated nuclear protein]]
[[Category: topoisomerase]]
 
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Latest revision as of 06:36, 7 February 2024

TOPOISOMERASE RESIDUES 410-1202,

1bgw, resolution 2.70Å

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