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New page: left|200px<br /> <applet load="2cha" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cha, resolution 2.0Å" /> '''THE STRUCTURE OF CRY...
 
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[[Image:2cha.gif|left|200px]]<br />
<applet load="2cha" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2cha, resolution 2.0&Aring;" />
'''THE STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN, $V.THE ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 ANGSTROMS RESOLUTION'''<br />


==About this Structure==
==THE STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN, $V.THE ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 ANGSTROMS RESOLUTION==
2CHA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with TOS as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 2CHA with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb46_1.html Trypsin]]. Active as [http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CHA OCA].  
<StructureSection load='2cha' size='340' side='right'caption='[[2cha]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cha]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The October 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Trypsin''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_10 10.2210/rcsb_pdb/mom_2003_10]. The October 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''PDB Pioneers''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_10 10.2210/rcsb_pdb/mom_2011_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TSU:PARA-TOLUENE+SULFONATE'>TSU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cha OCA], [https://pdbe.org/2cha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cha RCSB], [https://www.ebi.ac.uk/pdbsum/2cha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cha ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2cha_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cha ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution., Birktoft JJ, Blow DM, J Mol Biol. 1972 Jul 21;68(2):187-240. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=5069789 5069789]
*[[Chymotrypsin 3D structures|Chymotrypsin 3D structures]]
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Chymotrypsin]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: PDB Pioneers]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Trypsin]]
[[Category: Trypsin]]
[[Category: Birktoft, J.J.]]
[[Category: Birktoft JJ]]
[[Category: Blow, D.M.]]
[[Category: Blow DM]]
[[Category: TOS]]
[[Category: hydrolase (serine proteinase)]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:08:15 2007''

Latest revision as of 07:04, 27 September 2023

THE STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN, $V.THE ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 ANGSTROMS RESOLUTION

2cha, resolution 2.00Å

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