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New page: left|200px<br /><applet load="1dd9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dd9, resolution 1.6Å" /> '''STRUCTURE OF THE DNAG...
 
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[[Image:1dd9.jpg|left|200px]]<br /><applet load="1dd9" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1dd9, resolution 1.6&Aring;" />
'''STRUCTURE OF THE DNAG CATALYTIC CORE'''<br />


==Overview==
==STRUCTURE OF THE DNAG CATALYTIC CORE==
All cellular organisms use specialized RNA polymerases called "primases", to synthesize RNA primers for the initiation of DNA replication. The, high-resolution crystal structure of a primase, comprising the catalytic, core of the Escherichia coli DnaG protein, was determined. The core, structure contains an active-site architecture that is unrelated to other, DNA or RNA polymerase palm folds, but is instead related to the "toprim", fold. On the basis of the structure, it is likely that DnaG binds nucleic, acid in a groove clustered with invariant residues and that DnaG is, positioned within the replisome to accept single-stranded DNA directly, from the replicative helicase.
<StructureSection load='1dd9' size='340' side='right'caption='[[1dd9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1dd9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DD9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd9 OCA], [https://pdbe.org/1dd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dd9 RCSB], [https://www.ebi.ac.uk/pdbsum/1dd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNAG_ECOLI DNAG_ECOLI] RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.[HAMAP-Rule:MF_00974]<ref>PMID:1511009</ref> <ref>PMID:340457</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/1dd9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dd9 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1DD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DD9 OCA].
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
 
== References ==
==Reference==
<references/>
Structure of the RNA polymerase domain of E. coli primase., Keck JL, Roche DD, Lynch AS, Berger JM, Science. 2000 Mar 31;287(5462):2482-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10741967 10741967]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Berger, J.M.]]
[[Category: Berger JM]]
[[Category: Keck, J.L.]]
[[Category: Keck JL]]
[[Category: Lynch, A.S.]]
[[Category: Lynch AS]]
[[Category: Roche, D.D.]]
[[Category: Roche DD]]
[[Category: SR]]
[[Category: 3-helix bundle]]
[[Category: dna-binding protein]]
[[Category: primase]]
[[Category: replication protein]]
[[Category: rna polymerase]]
[[Category: toprim]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:11:27 2007''

Latest revision as of 06:52, 7 February 2024

STRUCTURE OF THE DNAG CATALYTIC CORE

1dd9, resolution 1.60Å

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