1dks: Difference between revisions

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{{Seed}}
[[Image:1dks.png|left|200px]]


<!--
==CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 IN COMPLEX WITH PHOSPHATE==
The line below this paragraph, containing "STRUCTURE_1dks", creates the "Structure Box" on the page.
<StructureSection load='1dks' size='340' side='right'caption='[[1dks]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DKS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_1dks| PDB=1dks |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dks OCA], [https://pdbe.org/1dks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dks RCSB], [https://www.ebi.ac.uk/pdbsum/1dks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dks ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CKS1_HUMAN CKS1_HUMAN] Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/1dks_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dks ConSurf].
<div style="clear:both"></div>


===CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 IN COMPLEX WITH PHOSPHATE===
==See Also==
 
*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
 
*[[Cyclin-dependent kinase regulatory subunit|Cyclin-dependent kinase regulatory subunit]]
<!--  
*[[Cyclin-dependent kinase regulatory subunit 3D structures|Cyclin-dependent kinase regulatory subunit 3D structures]]
The line below this paragraph, {{ABSTRACT_PUBMED_7791211}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 7791211 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_7791211}}
 
==About this Structure==
1DKS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DKS OCA].
 
==Reference==
Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain., Arvai AS, Bourne Y, Hickey MJ, Tainer JA, J Mol Biol. 1995 Jun 23;249(5):835-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7791211 7791211]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arvai, A S.]]
[[Category: Arvai AS]]
[[Category: Bourne, Y.]]
[[Category: Bourne Y]]
[[Category: Tainer, J A.]]
[[Category: Tainer JA]]
[[Category: Cell division]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:13:14 2008''

Latest revision as of 06:55, 7 February 2024

CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 IN COMPLEX WITH PHOSPHATE

1dks, resolution 3.20Å

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