1f6t: Difference between revisions

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{{Seed}}
[[Image:1f6t.png|left|200px]]


<!--
==STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX==
The line below this paragraph, containing "STRUCTURE_1f6t", creates the "Structure Box" on the page.
<StructureSection load='1f6t' size='340' side='right'caption='[[1f6t]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1f6t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F6T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TBD:2*-DEOXY-THYMIDINE-5*-ALPHA+BORANO+DIPHOSPHATE+(ISOMER+RP)'>TBD</scene></td></tr>
{{STRUCTURE_1f6t| PDB=1f6t |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f6t OCA], [https://pdbe.org/1f6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f6t RCSB], [https://www.ebi.ac.uk/pdbsum/1f6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f6t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NDKC_DICDI NDKC_DICDI]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/1f6t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f6t ConSurf].
<div style="clear:both"></div>


===STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX===
==See Also==
 
*[[Nucleoside diphosphate kinase 3D structures|Nucleoside diphosphate kinase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_10899107}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10899107 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10899107}}
 
==About this Structure==
1F6T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F6T OCA].
 
==Reference==
Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase., Meyer P, Schneider B, Sarfati S, Deville-Bonne D, Guerreiro C, Boretto J, Janin J, Veron M, Canard B, EMBO J. 2000 Jul 17;19(14):3520-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10899107 10899107]
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
[[Category: Nucleoside-diphosphate kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Boretto J]]
[[Category: Boretto, J.]]
[[Category: Canard B]]
[[Category: Canard, B.]]
[[Category: Deville-Bonne D]]
[[Category: Deville-Bonne, D.]]
[[Category: Guerreiro C]]
[[Category: Guerreiro, C.]]
[[Category: Janin J]]
[[Category: Janin, J.]]
[[Category: Sarfati S]]
[[Category: Sarfati, S.]]
[[Category: Schneider B]]
[[Category: Schneider, B.]]
[[Category: Veron M]]
[[Category: Veron, M.]]
[[Category: Anti-hiv nucleoside analogue]]
[[Category: Boranophosphate]]
[[Category: Crystallography]]
[[Category: Nucleoside diphosphate kinase]]
[[Category: Phosphorylation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:47:39 2008''

Latest revision as of 07:11, 7 February 2024

STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX

1f6t, resolution 1.92Å

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