1f73: Difference between revisions

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{{Seed}}
[[Image:1f73.png|left|200px]]


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==CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL==
The line below this paragraph, containing "STRUCTURE_1f73", creates the "Structure Box" on the page.
<StructureSection load='1f73' size='340' side='right'caption='[[1f73]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1f73]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F73 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HMN:2,4,6,7,8,9-HEXAHYDROXY-5-METHYLCARBOXAMIDO+NONANOIC+ACID'>HMN</scene></td></tr>
{{STRUCTURE_1f73| PDB=1f73 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f73 OCA], [https://pdbe.org/1f73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f73 RCSB], [https://www.ebi.ac.uk/pdbsum/1f73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f73 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NANA_HAEIN NANA_HAEIN] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/1f73_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f73 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL===
==See Also==
 
*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_11031117}}, adds the Publication Abstract to the page
[[Category: Haemophilus influenzae]]
(as it appears on PubMed at http://www.pubmed.gov), where 11031117 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Barbosa JARG]]
{{ABSTRACT_PUBMED_11031117}}
[[Category: DeGori R]]
 
[[Category: Lawrence MC]]
==About this Structure==
[[Category: Smith BJ]]
1F73 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemolphilus_influenzae Haemolphilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F73 OCA].
 
==Reference==
Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme., Barbosa JA, Smith BJ, DeGori R, Ooi HC, Marcuccio SM, Campi EM, Jackson WR, Brossmer R, Sommer M, Lawrence MC, J Mol Biol. 2000 Oct 27;303(3):405-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11031117 11031117]
[[Category: Haemolphilus influenzae]]
[[Category: N-acetylneuraminate lyase]]
[[Category: Single protein]]
[[Category: Barbosa, J A.R G.]]
[[Category: DeGori, R.]]
[[Category: Lawrence, M C.]]
[[Category: Smith, B J.]]
[[Category: Beta barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:48:19 2008''

Latest revision as of 07:11, 7 February 2024

CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL

1f73, resolution 1.95Å

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