1fds: Difference between revisions

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{{Seed}}
[[Image:1fds.png|left|200px]]


<!--
==HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH 17-BETA-ESTRADIOL==
The line below this paragraph, containing "STRUCTURE_1fds", creates the "Structure Box" on the page.
<StructureSection load='1fds' size='340' side='right'caption='[[1fds]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1fds]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FDS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene></td></tr>
{{STRUCTURE_1fds| PDB=1fds |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fds OCA], [https://pdbe.org/1fds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fds RCSB], [https://www.ebi.ac.uk/pdbsum/1fds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fds ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fd/1fds_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fds ConSurf].
<div style="clear:both"></div>


===HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH 17-BETA-ESTRADIOL===
==See Also==
 
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_8805577}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8805577 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8805577}}
 
==About this Structure==
1FDS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FDS OCA].
 
==Reference==
The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors., Breton R, Housset D, Mazza C, Fontecilla-Camps JC, Structure. 1996 Aug 15;4(8):905-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8805577 8805577]
[[Category: Estradiol 17-beta-dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Breton, R.]]
[[Category: Breton R]]
[[Category: Fontecilla-Camps, J C.]]
[[Category: Fontecilla-Camps J-C]]
[[Category: Housset, D.]]
[[Category: Housset D]]
[[Category: Mazza, C.]]
[[Category: Mazza C]]
[[Category: 17-beta-hydroxysteroid]]
[[Category: Dehydrogenase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:06:01 2008''

Latest revision as of 07:13, 7 February 2024

HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH 17-BETA-ESTRADIOL

1fds, resolution 1.70Å

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