1i69: Difference between revisions

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{{Seed}}
[[Image:1i69.png|left|200px]]


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==CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR==
The line below this paragraph, containing "STRUCTURE_1i69", creates the "Structure Box" on the page.
<StructureSection load='1i69' size='340' side='right'caption='[[1i69]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1i69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I69 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
{{STRUCTURE_1i69| PDB=1i69 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i69 OCA], [https://pdbe.org/1i69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i69 RCSB], [https://www.ebi.ac.uk/pdbsum/1i69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i69 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OXYR_ECOLI OXYR_ECOLI] Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/1i69_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i69 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR===
==See Also==
 
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_11301006}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11301006 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11301006}}
 
==About this Structure==
1I69 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I69 OCA].
 
==Reference==
Structural basis of the redox switch in the OxyR transcription factor., Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu S, Cell. 2001 Apr 6;105(1):103-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11301006 11301006]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Choi, H.]]
[[Category: Choi H]]
[[Category: Kim, S.]]
[[Category: Kim S]]
[[Category: Ryu, S.]]
[[Category: Ryu S]]
[[Category: Oxyr regulatory domain]]
[[Category: Reduced form]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:28:25 2008''

Latest revision as of 07:32, 7 February 2024

CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR

1i69, resolution 2.70Å

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