2k4a: Difference between revisions
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New page: '''Unreleased structure''' The entry 2k4a is ON HOLD until Paper Publication Authors: Yu, C., Mohan, S.K. Description: FGF-1-C2A binary complex structure: a key component in the fibrob... |
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==FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway== | |||
<StructureSection load='2k4a' size='340' side='right'caption='[[2k4a]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2k4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K4A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4a OCA], [https://pdbe.org/2k4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k4a RCSB], [https://www.ebi.ac.uk/pdbsum/2k4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4a ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/2k4a_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k4a ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]] | |||
*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mohan SK]] | |||
[[Category: Yu C]] | |||
Latest revision as of 19:10, 29 May 2024
FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway
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