1n3n: Difference between revisions
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New page: left|200px<br /><applet load="1n3n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n3n, resolution 3.0Å" /> '''Crystal structure of ... |
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== | ==Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db== | ||
The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock | <StructureSection load='1n3n' size='340' side='right'caption='[[1n3n]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1n3n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N3N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3n OCA], [https://pdbe.org/1n3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n3n RCSB], [https://www.ebi.ac.uk/pdbsum/1n3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n3n ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/1n3n_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n3n ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in complex with the murine class I major histocompatibility complex molecule H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but does not recognize the nonameric mycobacterial peptide SALQNAASI. Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune pathology in immunodeficient mice. We solved the X-ray crystal structure of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight into T-cell receptor cross-reactivity. | |||
Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db.,Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:12753896<ref>PMID:12753896</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
<div class="pdbe-citations 1n3n" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | |||
*[[MHC 3D structures|MHC 3D structures]] | |||
*[[MHC I 3D structures|MHC I 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Capitani G]] | |||
[[Category: Capitani | [[Category: Ciatto C]] | ||
[[Category: Ciatto | [[Category: Grutter MG]] | ||
[[Category: Grutter | [[Category: Pecorari F]] | ||
[[Category: Pecorari | [[Category: Pluckthun A]] | ||
[[Category: Pluckthun | [[Category: Tissot AC]] | ||
[[Category: Tissot | |||
Latest revision as of 08:39, 6 November 2024
Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db
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