2b6b: Difference between revisions

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{{Seed}}
[[Image:2b6b.png|left|200px]]


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==Cryo EM structure of Dengue complexed with CRD of DC-SIGN==
The line below this paragraph, containing "STRUCTURE_2b6b", creates the "Structure Box" on the page.
<SX load='2b6b' size='340' side='right' viewer='molstar' caption='[[2b6b]], [[Resolution|resolution]] 25.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2b6b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B6B FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 25&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6b OCA], [https://pdbe.org/2b6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b6b RCSB], [https://www.ebi.ac.uk/pdbsum/2b6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b6b ProSAT]</span></td></tr>
{{STRUCTURE_2b6b|  PDB=2b6b  |  SCENE=  }}
</table>
 
== Function ==
===Cryo EM structure of Dengue complexed with CRD of DC-SIGN===
[https://www.uniprot.org/uniprot/Q9WDA7_9FLAV Q9WDA7_9FLAV] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317]  Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504]  Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859]
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_16469696}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 16469696 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b6b_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16469696}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Disease==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b6b ConSurf].
Known disease associated with this structure: Dengue fever, protection against OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]], HIV type 1, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]], Mycobacterium tuberculosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]]
<div style="clear:both"></div>
 
__TOC__
==About this Structure==
</SX>
2B6B is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6B OCA].  
 
==Reference==
Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN., Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG, Cell. 2006 Feb 10;124(3):485-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16469696 16469696]
[[Category: Dengue virus]]
[[Category: Dengue virus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Bator-Kelly, C M.]]
[[Category: Bator-Kelly CM]]
[[Category: Battisti, A J.]]
[[Category: Battisti AJ]]
[[Category: Chipman, P R.]]
[[Category: Chipman PR]]
[[Category: Gregorio, G.]]
[[Category: Gregorio G]]
[[Category: Hendrickson, W A.]]
[[Category: Hendrickson WA]]
[[Category: Kuhn, R J.]]
[[Category: Kuhn RJ]]
[[Category: Pokidysheva, E.]]
[[Category: Pokidysheva E]]
[[Category: Rossmann, M G.]]
[[Category: Rossmann MG]]
[[Category: Zhang, Y.]]
[[Category: Zhang Y]]
[[Category: Cryo em dengue crd dc-sign]]
[[Category: Icosahedral virus]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:27:17 2008''

Latest revision as of 09:16, 14 February 2024

Cryo EM structure of Dengue complexed with CRD of DC-SIGN

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