2r5a: Difference between revisions

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{{Seed}}
[[Image:2r5a.png|left|200px]]


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==Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in complex with methyl lysine==
The line below this paragraph, containing "STRUCTURE_2r5a", creates the "Structure Box" on the page.
<StructureSection load='2r5a' size='340' side='right'caption='[[2r5a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2r5a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
{{STRUCTURE_2r5a| PDB=2r5a |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5a OCA], [https://pdbe.org/2r5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5a RCSB], [https://www.ebi.ac.uk/pdbsum/2r5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCM_DROME SCM_DROME] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.<ref>PMID:15280237</ref> [UniProtKB:Q9W3C1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5a ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in complex with methyl lysine===
==See Also==
 
*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
 
== References ==
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</StructureSection>
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{{ABSTRACT_PUBMED_17932512}}
 
==About this Structure==
2R5A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5A OCA].
 
==Reference==
Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg., Grimm C, de Ayala Alonso AG, Rybin V, Steuerwald U, Ly-Hartig N, Fischle W, Muller J, Muller CW, EMBO Rep. 2007 Nov;8(11):1031-7. Epub 2007 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17932512 17932512]
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Grimm, C.]]
[[Category: Grimm C]]
[[Category: Mueller, C W.]]
[[Category: Mueller CW]]
[[Category: Steuerwald, U.]]
[[Category: Steuerwald U]]
[[Category: Chromatin regulator]]
[[Category: Developmental protein]]
[[Category: Mbt]]
[[Category: Mbt repeat]]
[[Category: Metal-binding]]
[[Category: Nucleus]]
[[Category: Polycomb]]
[[Category: Repressor]]
[[Category: Scm]]
[[Category: Sex comb on midleg]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:48:32 2008''

Latest revision as of 09:19, 21 February 2024

Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in complex with methyl lysine

2r5a, resolution 2.30Å

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