1y5m: Difference between revisions

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{{Seed}}
[[Image:1y5m.png|left|200px]]


<!--
==The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes==
The line below this paragraph, containing "STRUCTURE_1y5m", creates the "Structure Box" on the page.
<StructureSection load='1y5m' size='340' side='right'caption='[[1y5m]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1y5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y5M FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1y5m| PDB=1y5m |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y5m OCA], [https://pdbe.org/1y5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y5m RCSB], [https://www.ebi.ac.uk/pdbsum/1y5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y5m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y5/1y5m_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y5m ConSurf].
<div style="clear:both"></div>


===The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes===
==See Also==
 
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_15865440}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 15865440 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15865440}}
 
==About this Structure==
1Y5M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y5M OCA].
 
==Reference==
Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes., Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR, Biochemistry. 2005 May 10;44(18):6948-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15865440 15865440]
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Clogston CL]]
[[Category: Clogston, C L.]]
[[Category: Delaney JM]]
[[Category: Delaney, J M.]]
[[Category: Jordan SR]]
[[Category: Jordan, S R.]]
[[Category: Nybo RE]]
[[Category: Nybo, R E.]]
[[Category: Osslund TD]]
[[Category: Osslund, T D.]]
[[Category: Plant MH]]
[[Category: Plant, M H.]]
[[Category: Xiong F]]
[[Category: Xiong, F.]]
[[Category: Zhang J]]
[[Category: Zhang, J.]]
[[Category: Rossmann fold]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:18:50 2008''

Latest revision as of 08:55, 14 February 2024

The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes

1y5m, resolution 2.30Å

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