2pth: Difference between revisions

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{{Seed}}
[[Image:2pth.png|left|200px]]


<!--
==PEPTIDYL-TRNA HYDROLASE FROM ESCHERICHIA COLI==
The line below this paragraph, containing "STRUCTURE_2pth", creates the "Structure Box" on the page.
<StructureSection load='2pth' size='340' side='right'caption='[[2pth]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PTH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pth OCA], [https://pdbe.org/2pth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pth RCSB], [https://www.ebi.ac.uk/pdbsum/2pth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pth ProSAT]</span></td></tr>
{{STRUCTURE_2pth| PDB=2pth |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTH_ECOLI PTH_ECOLI] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pt/2pth_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pth ConSurf].
<div style="clear:both"></div>


===PEPTIDYL-TRNA HYDROLASE FROM ESCHERICHIA COLI===
==See Also==
 
*[[Peptidyl-tRNA hydrolase|Peptidyl-tRNA hydrolase]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_9303320}}, adds the Publication Abstract to the page
[[Category: Escherichia coli K-12]]
(as it appears on PubMed at http://www.pubmed.gov), where 9303320 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Blanquet S]]
{{ABSTRACT_PUBMED_9303320}}
[[Category: Fromant M]]
 
[[Category: Mechulam Y]]
==About this Structure==
[[Category: Plateau P]]
2PTH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PTH OCA].
[[Category: Schmitt E]]
 
==Reference==
Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase., Schmitt E, Mechulam Y, Fromant M, Plateau P, Blanquet S, EMBO J. 1997 Aug 1;16(15):4760-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9303320 9303320]
[[Category: Aminoacyl-tRNA hydrolase]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Blanquet, S.]]
[[Category: Fromant, M.]]
[[Category: Mechulam, Y.]]
[[Category: Plateau, P.]]
[[Category: Schmitt, E.]]
[[Category: Hydrolase]]
[[Category: Peptidyl-trna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:03:08 2008''

Latest revision as of 09:11, 21 February 2024

PEPTIDYL-TRNA HYDROLASE FROM ESCHERICHIA COLI

2pth, resolution 1.20Å

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