3c92: Difference between revisions

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{{Seed}}
[[Image:3c92.jpg|left|200px]]


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==Thermoplasma acidophilum 20S proteasome with a closed gate==
The line below this paragraph, containing "STRUCTURE_3c92", creates the "Structure Box" on the page.
<SX load='3c92' size='340' side='right' viewer='molstar' caption='[[3c92]], [[Resolution|resolution]] 6.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3c92]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C92 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c92 OCA], [https://pdbe.org/3c92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c92 RCSB], [https://www.ebi.ac.uk/pdbsum/3c92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c92 ProSAT]</span></td></tr>
{{STRUCTURE_3c92| PDB=3c92 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA_THEAC PSA_THEAC] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.<ref>PMID:8999862</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c92_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c92 ConSurf].
<div style="clear:both"></div>


===Thermoplasma acidophilum 20S proteasome with a closed gate===
==See Also==
 
*[[Proteasome 3D structures|Proteasome 3D structures]]
 
== References ==
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_18471981}}
 
==About this Structure==
3C92 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C92 OCA].
 
==Reference==
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases., Rabl J, Smith DM, Yu Y, Chang SC, Goldberg AL, Cheng Y, Mol Cell. 2008 May 9;30(3):360-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18471981 18471981]
[[Category: Proteasome endopeptidase complex]]
[[Category: Protein complex]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
[[Category: Chang, S C.]]
[[Category: Chang SC]]
[[Category: Cheng, Y.]]
[[Category: Cheng Y]]
[[Category: Goldberg, A L.]]
[[Category: Goldberg AL]]
[[Category: Rabl, J.]]
[[Category: Rabl J]]
[[Category: Smith, D M.]]
[[Category: Smith DM]]
[[Category: Yu, Y.]]
[[Category: Yu Y]]
[[Category: Cytoplasm]]
[[Category: Hydrolase]]
[[Category: Protease]]
[[Category: Proteasome]]
[[Category: Protein complex]]
[[Category: Threonine protease]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug  6 12:57:59 2008''

Latest revision as of 09:33, 21 February 2024

Thermoplasma acidophilum 20S proteasome with a closed gate

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