2rf6: Difference between revisions

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{{Seed}}
[[Image:2rf6.jpg|left|200px]]


<!--
==Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1==
The line below this paragraph, containing "STRUCTURE_2rf6", creates the "Structure Box" on the page.
<StructureSection load='2rf6' size='340' side='right'caption='[[2rf6]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2rf6| PDB=2rf6 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf6 OCA], [https://pdbe.org/2rf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf6 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUSP_VACCW DUSP_VACCW] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.<ref>PMID:10438817</ref> <ref>PMID:11238845</ref> <ref>PMID:1848923</ref> <ref>PMID:18593332</ref> <ref>PMID:21362620</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rf6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rf6 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1===
==See Also==
 
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2RF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF6 OCA].
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Vaccinia virus]]
[[Category: Large Structures]]
[[Category: Cingolani, G.]]
[[Category: Koksal, A C.]]
[[Category: Dual-specificity phosphatase]]
[[Category: Hydrolase]]
[[Category: Late protein]]
[[Category: Protein phosphatase]]
[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
[[Category: Vh1]]
[[Category: Cingolani G]]
 
[[Category: Koksal AC]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  1 21:35:15 2008''

Latest revision as of 11:55, 30 August 2023

Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1

2rf6, resolution 1.95Å

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