1t0m: Difference between revisions

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New page: left|200px<br /><applet load="1t0m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t0m, resolution 2.0Å" /> '''Conformational switch...
 
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[[Image:1t0m.jpg|left|200px]]<br /><applet load="1t0m" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1t0m, resolution 2.0&Aring;" />
'''Conformational switch in polymorphic H-2K molecules containing an HSV peptide'''<br />


==Overview==
==Conformational switch in polymorphic H-2K molecules containing an HSV peptide==
Polymorphism within the MHC not only affects peptide specificity but also, has a critical influence on the T cell repertoire; for example, the CD8 T, cell response toward an immunodominant HSV glycoprotein B peptide is more, diverse and of higher avidity in H-2(bm8) compared with H-2(b) mice. We, have examined the basis for the selection of these distinct antiviral T, cell repertoires by comparing the high-resolution structures of K(b) and, K(bm8), in complex with cognate peptide Ag. Although K(b) and K(bm8), differ by four residues within the Ag-binding cleft, the most striking, difference in the two structures was the disparate conformation adopted by, the shared residue, Arg(62). The altered dynamics of Arg(62), coupled with, a small rigid-body movement in the alpha(1) helix encompassing this, residue, correlated with biased Valpha usage in the B6 mice. Moreover, an, analysis of all known TCR/MHC complexes reveals that Arg(62) invariably, interacts with the TCR CDR1alpha loop. Accordingly, Arg(62) appears to, function as a conformational switch that may govern T cell selection and, protective immunity.
<StructureSection load='1t0m' size='340' side='right'caption='[[1t0m]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1t0m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_F Human alphaherpesvirus 1 strain F] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T0M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t0m OCA], [https://pdbe.org/1t0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t0m RCSB], [https://www.ebi.ac.uk/pdbsum/1t0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t0m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t0/1t0m_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t0m ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1T0M is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1T0M OCA].
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
 
*[[MHC 3D structures|MHC 3D structures]]
==Reference==
*[[MHC I 3D structures|MHC I 3D structures]]
The structure of H-2K(b) and K(bm8) complexed to a herpes simplex virus determinant: evidence for a conformational switch that governs T cell repertoire selection and viral resistance., Webb AI, Borg NA, Dunstone MA, Kjer-Nielsen L, Beddoe T, McCluskey J, Carbone FR, Bottomley SP, Aguilar MI, Purcell AW, Rossjohn J, J Immunol. 2004 Jul 1;173(1):402-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15210799 15210799]
__TOC__
</StructureSection>
[[Category: Human alphaherpesvirus 1 strain F]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Beddoe T]]
[[Category: Beddoe, T.]]
[[Category: Borg NA]]
[[Category: Borg, N.A.]]
[[Category: Bottomley SP]]
[[Category: Bottomley, S.P.]]
[[Category: Carbone FR]]
[[Category: Carbone, F.R.]]
[[Category: Dunstone MA]]
[[Category: Dunstone, M.A.]]
[[Category: Kjer-Nielsen L]]
[[Category: Kjer-Nielsen, L.]]
[[Category: McCluskey J]]
[[Category: McCluskey, J.]]
[[Category: Purcell AW]]
[[Category: Purcell, A.W.]]
[[Category: Rossjohn J]]
[[Category: Rossjohn, J.]]
[[Category: Webb AI]]
[[Category: Webb, A.I.]]
[[Category: hsv peptide]]
[[Category: immunoglobulin domain]]
[[Category: mhc class i alpha domains]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:53:56 2007''

Latest revision as of 08:37, 1 May 2024

Conformational switch in polymorphic H-2K molecules containing an HSV peptide

1t0m, resolution 2.00Å

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