3f5c: Difference between revisions

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{{Seed}}
[[Image:3f5c.jpg|left|200px]]


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==Structure of Dax-1:LRH-1 complex==
The line below this paragraph, containing "STRUCTURE_3f5c", creates the "Structure Box" on the page.
<StructureSection load='3f5c' size='340' side='right'caption='[[3f5c]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3f5c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5C FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5c OCA], [https://pdbe.org/3f5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5c RCSB], [https://www.ebi.ac.uk/pdbsum/3f5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5c ProSAT]</span></td></tr>
{{STRUCTURE_3f5c|  PDB=3f5c  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR5A2_MOUSE NR5A2_MOUSE] Binds to promoters containing the sequence element 5'-AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate Dax-1 function. The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor.


===Structure of Dax-1:LRH-1 complex===
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.,Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. Epub 2008 Nov 17. PMID:19015525<ref>PMID:19015525</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3f5c" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19015525}}, adds the Publication Abstract to the page
*[[Liver receptor homolog-1|Liver receptor homolog-1]]
(as it appears on PubMed at http://www.pubmed.gov), where 19015525 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19015525}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3F5C is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA].
 
==Reference==
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1., Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ, Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. Epub 2008 Nov 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19015525 19015525]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Fletterick, R J.]]
[[Category: Fletterick RJ]]
[[Category: Sablin, E P.]]
[[Category: Sablin EP]]
[[Category: Cytoplasm]]
[[Category: Dna-binding]]
[[Category: Lipid-binding]]
[[Category: Metal-binding]]
[[Category: Nuclear receptor]]
[[Category: Nucleus]]
[[Category: Receptor]]
[[Category: Regulatory complex]]
[[Category: Repressor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcriptional corepressor]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:35:58 2008''

Latest revision as of 13:13, 26 July 2023

Structure of Dax-1:LRH-1 complex

3f5c, resolution 3.00Å

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