1y6k: Difference between revisions

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{{Seed}}
[[Image:1y6k.png|left|200px]]


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==Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain==
The line below this paragraph, containing "STRUCTURE_1y6k", creates the "Structure Box" on the page.
<StructureSection load='1y6k' size='340' side='right'caption='[[1y6k]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1y6k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y6K FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6k OCA], [https://pdbe.org/1y6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y6k RCSB], [https://www.ebi.ac.uk/pdbsum/1y6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y6k ProSAT]</span></td></tr>
{{STRUCTURE_1y6k|  PDB=1y6k  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL10_HUMAN IL10_HUMAN] Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y6/1y6k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y6k ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human IL-10 (hIL-10) is a cytokine that modulates diverse immune responses. The Epstein-Barr virus (EBV) genome contains an IL-10 homolog (vIL-10) that shares high sequence and structural similarity with hIL-10. Although vIL-10 suppresses inflammatory responses like hIL-10, it cannot activate many other immunostimulatory functions performed by the cellular cytokine. These functional differences have been correlated with the approximately 1000-fold lower affinity of vIL-10, compared to hIL-10, for the IL-10R1 receptor chain. To define the structural basis for these observations, crystal structures of vIL-10 and a vIL-10 point mutant were determined bound to the soluble IL-10R1 receptor fragment (sIL-10R1) at 2.8 and 2.7 A resolution, respectively. The structures reveal that subtle changes in the conformation and dynamics of the vIL-10 AB and CD loops and an orientation change of vIL-10 on sIL-10R1 are the main factors responsible for vIL-10's reduced affinity for sIL-10R1 and its distinct biological profile.


===Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain===
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.,Yoon SI, Jones BC, Logsdon NJ, Walter MR Structure. 2005 Apr;13(4):551-64. PMID:15837194<ref>PMID:15837194</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1y6k" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_15837194}}, adds the Publication Abstract to the page
*[[Interleukin 3D structures|Interleukin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 15837194 is the PubMed ID number.
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
-->
== References ==
{{ABSTRACT_PUBMED_15837194}}
<references/>
 
__TOC__
==Disease==
</StructureSection>
Known disease associated with this structure: Graft-versus-host disease, protection against OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=124092 124092]], HIV-1, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=124092 124092]], Rheumatoid arthritis, progression of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=124092 124092]]
 
==About this Structure==
1Y6K is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6K OCA].
 
==Reference==
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain., Yoon SI, Jones BC, Logsdon NJ, Walter MR, Structure. 2005 Apr;13(4):551-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15837194 15837194]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Jones, B C.]]
[[Category: Large Structures]]
[[Category: Josepson, K.]]
[[Category: Jones BC]]
[[Category: Logsdon, N J.]]
[[Category: Josepson K]]
[[Category: Walter, M R.]]
[[Category: Logsdon NJ]]
[[Category: Yoon, S I.]]
[[Category: Walter MR]]
[[Category: Helix bundle]]
[[Category: Yoon SI]]
[[Category: Immune system]]
[[Category: Receptor complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 09:12:28 2008''

Latest revision as of 07:31, 9 October 2024

Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain

1y6k, resolution 2.52Å

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