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New page: left|200px<br /><applet load="1xpp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xpp, resolution 1.60Å" /> '''Crystal Structure of...
 
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[[Image:1xpp.jpg|left|200px]]<br /><applet load="1xpp" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1xpp, resolution 1.60&Aring;" />
'''Crystal Structure of TA1416,DNA-directed RNA polymerase subunit L, from Thermoplasma acidophilum'''<br />


==About this Structure==
==Crystal Structure of TA1416,DNA-directed RNA polymerase subunit L, from Thermoplasma acidophilum==
1XPP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum] with SCN, FMT and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XPP OCA].  
<StructureSection load='1xpp' size='340' side='right'caption='[[1xpp]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
[[Category: DNA-directed RNA polymerase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[1xpp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XPP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpp OCA], [https://pdbe.org/1xpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xpp RCSB], [https://www.ebi.ac.uk/pdbsum/1xpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpp ProSAT], [https://www.topsan.org/Proteins/MCSG/1xpp TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPO11_THEAC RPO11_THEAC] DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00261]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xpp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xpp ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Evdokimova, E.]]
[[Category: Evdokimova E]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: Kim, Y.]]
[[Category: Kim Y]]
[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
[[Category: Savchenko A]]
[[Category: Savchenko, A.]]
[[Category: ACY]]
[[Category: FMT]]
[[Category: SCN]]
[[Category: dna-directed rna polymerase]]
[[Category: mcsg]]
[[Category: midwest center for structural genomics]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomics]]
[[Category: thermoplasma acidophilum]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:15:04 2007''

Latest revision as of 08:52, 14 February 2024

Crystal Structure of TA1416,DNA-directed RNA polymerase subunit L, from Thermoplasma acidophilum

1xpp, resolution 1.60Å

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