2q5e: Difference between revisions

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{{Seed}}
[[Image:2q5e.png|left|200px]]


<!--
==Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2==
The line below this paragraph, containing "STRUCTURE_2q5e", creates the "Structure Box" on the page.
<StructureSection load='2q5e' size='340' side='right'caption='[[2q5e]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2q5e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q5E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2q5e| PDB=2q5e |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q5e OCA], [https://pdbe.org/2q5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q5e RCSB], [https://www.ebi.ac.uk/pdbsum/2q5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q5e ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2q5e TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CTDS2_HUMAN CTDS2_HUMAN] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.<ref>PMID:12721286</ref> <ref>PMID:15681389</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/2q5e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q5e ConSurf].
<div style="clear:both"></div>


===Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2===
==See Also==
 
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_18058037}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 18058037 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_18058037}}
 
==About this Structure==
2Q5E is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5E OCA].
 
==Reference==
<ref group="xtra">PMID:18058037</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Large Structures]]
[[Category: Almo, S C.]]
[[Category: Almo SC]]
[[Category: Bain, K T.]]
[[Category: Bain KT]]
[[Category: Bonanno, J B.]]
[[Category: Bonanno JB]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Dickey, M.]]
[[Category: Dickey M]]
[[Category: Lau, C.]]
[[Category: Lau C]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Romero R]]
[[Category: Romero, R.]]
[[Category: Sauder JM]]
[[Category: Sauder, J M.]]
[[Category: Smith D]]
[[Category: Smith, D.]]
[[Category: Wasserman S]]
[[Category: Wasserman, S.]]
[[Category: Hydrolase]]
[[Category: New york structural genomix research consortium]]
[[Category: Nysgxrc]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:47:21 2009''

Latest revision as of 09:14, 21 February 2024

Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

2q5e, resolution 2.51Å

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