3dkm: Difference between revisions
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< | ==Crystal structure of the HECTD1 CPH domain== | ||
<StructureSection load='3dkm' size='340' side='right'caption='[[3dkm]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3dkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DKM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkm OCA], [https://pdbe.org/3dkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dkm RCSB], [https://www.ebi.ac.uk/pdbsum/3dkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HECD1_HUMAN HECD1_HUMAN] Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/3dkm_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dkm ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bochkarev | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bochkarev A]] | ||
[[Category: Dhe-Paganon | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Dhe-Paganon S]] | ||
[[Category: Li | [[Category: Edwards AM]] | ||
[[Category: Qiu | [[Category: Li Y]] | ||
[[Category: Qiu L]] | |||
[[Category: Walker | [[Category: Walker JR]] | ||
[[Category: Wolkstrom | [[Category: Wolkstrom M]] | ||
Latest revision as of 12:48, 30 August 2023
Crystal structure of the HECTD1 CPH domain
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