1a6s: Difference between revisions

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{{Seed}}
[[Image:1a6s.png|left|200px]]


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==M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES==
The line below this paragraph, containing "STRUCTURE_1a6s", creates the "Structure Box" on the page.
<StructureSection load='1a6s' size='340' side='right'caption='[[1a6s]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus_-_Prague_C Rous sarcoma virus - Prague C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A6S FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6s OCA], [https://pdbe.org/1a6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a6s RCSB], [https://www.ebi.ac.uk/pdbsum/1a6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a6s ProSAT]</span></td></tr>
{{STRUCTURE_1a6s|  PDB=1a6s  |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).  The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/1a6s_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a6s ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A biologically active construct of the retroviral M domain from the avian Rous sarcoma virus is defined and its solution structure described. This M domain is fully active in budding and infectivity without myristylation. In spite of a sequence homology level that suggests no relationship among M domains and the family of matrix proteins in mammalian retroviruses, the conserved structural elements of a central core allow an M domain sequence motif to be described for all retroviruses. The surface of the M domain has a highly clustered positive patch comprised of sequentially distant residues. An analysis of the backbone dynamics, incorporating rotational anisotropy, is used to estimate the thermodynamics of proposed domain oligomerization.


===M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES===
Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus.,McDonnell JM, Fushman D, Cahill SM, Zhou W, Wolven A, Wilson CB, Nelle TD, Resh MD, Wills J, Cowburn D J Mol Biol. 1998 Jun 19;279(4):921-8. PMID:9642071<ref>PMID:9642071</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1a6s" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_9642071}}, adds the Publication Abstract to the page
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 9642071 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_9642071}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1A6S is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6S OCA].
[[Category: Rous sarcoma virus - Prague C]]
 
[[Category: Cahill SM]]
==Reference==
[[Category: Cowburn D]]
<ref group="xtra">PMID:9642071</ref><references group="xtra"/>
[[Category: Fushman D]]
[[Category: Rous sarcoma virus]]
[[Category: Mcdonnell JM]]
[[Category: Cahill, S M.]]
[[Category: Nelle TD]]
[[Category: Cowburn, D.]]
[[Category: Resh MD]]
[[Category: Fushman, D.]]
[[Category: Wills J]]
[[Category: Mcdonnell, J M.]]
[[Category: Wilson CB]]
[[Category: Nelle, T D.]]
[[Category: Wolven A]]
[[Category: Resh, M D.]]
[[Category: Zhou W]]
[[Category: Wills, J.]]
[[Category: Wilson, C B.]]
[[Category: Wolven, A.]]
[[Category: Zhou, W.]]
[[Category: Core protein]]
[[Category: Membrane binding]]
[[Category: Virus structure]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:53:32 2009''

Latest revision as of 08:11, 22 May 2024

M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES

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