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New page: left|200px<br /><applet load="2gza" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gza, resolution 2.600Å" /> '''Crystal structure o...
 
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[[Image:2gza.gif|left|200px]]<br /><applet load="2gza" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2gza, resolution 2.600&Aring;" />
'''Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate'''<br />


==Overview==
==Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate==
VirB11 ATPases are hexameric assemblies that power type IV secretion, systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like, that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring, structure formed by the N-terminal and C-terminal domains of each monomer., However, the monomer differs dramatically from that of Hp0525 by a large, domain swap that leaves the hexameric assembly intact but profoundly, alters the nucleotide-binding site and the interface between subunits.
<StructureSection load='2gza' size='340' side='right'caption='[[2gza]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2gza]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_suis_1330 Brucella suis 1330]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GZA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gza OCA], [https://pdbe.org/2gza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gza RCSB], [https://www.ebi.ac.uk/pdbsum/2gza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gza ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VIRBB_BRUSU VIRBB_BRUSU] The VirB system could be required for the establishment of the replication niche in the host.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/2gza_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gza ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
VirB11 ATPases are hexameric assemblies that power type IV secretion systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring structure formed by the N-terminal and C-terminal domains of each monomer. However, the monomer differs dramatically from that of Hp0525 by a large domain swap that leaves the hexameric assembly intact but profoundly alters the nucleotide-binding site and the interface between subunits.


==About this Structure==
A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact.,Hare S, Bayliss R, Baron C, Waksman G J Mol Biol. 2006 Jun 30;360(1):56-66. Epub 2006 May 11. PMID:16730027<ref>PMID:16730027</ref>
2GZA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brucella_suis Brucella suis] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GZA OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact., Hare S, Bayliss R, Baron C, Waksman G, J Mol Biol. 2006 Jun 30;360(1):56-66. Epub 2006 May 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16730027 16730027]
</div>
[[Category: Brucella suis]]
<div class="pdbe-citations 2gza" style="background-color:#fffaf0;"></div>
[[Category: H(+)-transporting two-sector ATPase]]
== References ==
[[Category: Single protein]]
<references/>
[[Category: Baron, C.]]
__TOC__
[[Category: Bayliss, R.]]
</StructureSection>
[[Category: Hare, S.]]
[[Category: Brucella suis 1330]]
[[Category: Waksman, G]]
[[Category: Large Structures]]
[[Category: SO4]]
[[Category: Baron C]]
[[Category: atpase]]
[[Category: Bayliss R]]
[[Category: secretion]]
[[Category: Hare S]]
 
[[Category: Waksman G]]
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