3g43: Difference between revisions

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{{Seed}}
[[Image:3g43.png|left|200px]]


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==Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer==
The line below this paragraph, containing "STRUCTURE_3g43", creates the "Structure Box" on the page.
<StructureSection load='3g43' size='340' side='right'caption='[[3g43]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3g43]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G43 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_3g43| PDB=3g43 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g43 OCA], [https://pdbe.org/3g43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g43 RCSB], [https://www.ebi.ac.uk/pdbsum/3g43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g43 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.  The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
== Function ==
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g43_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g43 ConSurf].
<div style="clear:both"></div>


===Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer===
==See Also==
 
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
 
*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_19279214}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 19279214 is the PubMed ID number.
__TOC__
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</StructureSection>
{{ABSTRACT_PUBMED_19279214}}
 
==About this Structure==
3G43 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G43 OCA].
 
==Reference==
<ref group="xtra">PMID:19279214</ref><ref group="xtra">PMID:16338416</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fallon, J L.]]
[[Category: Large Structures]]
[[Category: Quiocho, F A.]]
[[Category: Fallon JL]]
[[Category: Acetylation]]
[[Category: Quiocho FA]]
[[Category: Alternative splicing]]
[[Category: Brugada syndrome]]
[[Category: Calcium]]
[[Category: Calcium channel]]
[[Category: Calcium transport]]
[[Category: Calmodulin-bound]]
[[Category: Coiled coil]]
[[Category: Disease mutation]]
[[Category: Glycoprotein]]
[[Category: Ion transport]]
[[Category: Ionic channel]]
[[Category: Membrane]]
[[Category: Metal binding protein]]
[[Category: Methylation]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Ubl conjugation]]
[[Category: Voltage-gated channel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  8 20:13:10 2009''

Latest revision as of 09:52, 21 February 2024

Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer

3g43, resolution 2.10Å

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