3g3z: Difference between revisions

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{{Seed}}
[[Image:3g3z.png|left|200px]]


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==The structure of NMB1585, a MarR family regulator from Neisseria meningitidis==
The line below this paragraph, containing "STRUCTURE_3g3z", creates the "Structure Box" on the page.
<StructureSection load='3g3z' size='340' side='right'caption='[[3g3z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3g3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_B Neisseria meningitidis serogroup B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3Z FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_3g3z|  PDB=3g3z  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3z OCA], [https://pdbe.org/3g3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3z RCSB], [https://www.ebi.ac.uk/pdbsum/3g3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9JYH5_NEIMB Q9JYH5_NEIMB]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/3g3z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g3z ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the MarR-family transcription factor NMB1585 from Neisseria meningitidis has been solved using data extending to a resolution of 2.1 A. Overall, the dimeric structure resembles those of other MarR proteins, with each subunit comprising a winged helix-turn-helix (wHtH) domain connected to an alpha-helical dimerization domain. The spacing of the recognition helices of the wHtH domain indicates that NMB1585 is pre-configured for DNA binding, with a putative inducer pocket that is largely occluded by the side chains of two aromatic residues (Tyr29 and Trp53). NMB1585 was shown to bind to its own promoter region in a gel-shift assay, indicating that the protein acts as an auto-repressor.


===The structure of NMB1585, a MarR family regulator from Neisseria meningitidis===
The structure of NMB1585, a MarR-family regulator from Neisseria meningitidis.,Nichols CE, Sainsbury S, Ren J, Walter TS, Verma A, Stammers DK, Saunders NJ, Owens RJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt, 3):204-9. Epub 2009 Feb 26. PMID:19255465<ref>PMID:19255465</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3g3z" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19255465}}, adds the Publication Abstract to the page
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19255465 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19255465}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3G3Z is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Z OCA].
[[Category: Neisseria meningitidis serogroup B]]
 
[[Category: Nichols CE]]
==Reference==
[[Category: Owens RJ]]
<ref group="xtra">PMID:19255465</ref><references group="xtra"/>
[[Category: Ren J]]
[[Category: Neisseria meningitidis serogroup b]]
[[Category: Sainsbury S]]
[[Category: Nichols, C E.]]
[[Category: Saunders NJ]]
[[Category: OPPF, Oxford Protein Production Facility.]]
[[Category: Stammers DK]]
[[Category: Owens, R J.]]
[[Category: Verma A]]
[[Category: Ren, J.]]
[[Category: Walter TS]]
[[Category: Sainsbury, S.]]
[[Category: Saunders, N J.]]
[[Category: Stammers, D K.]]
[[Category: Verma, A.]]
[[Category: Walter, T S.]]
[[Category: Marr]]
[[Category: Neisseria meningitidi]]
[[Category: Oppf]]
[[Category: Oxford protein production facility]]
[[Category: Structural genomic]]
[[Category: Transcription factor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  6 10:02:55 2009''

Latest revision as of 09:10, 30 October 2024

The structure of NMB1585, a MarR family regulator from Neisseria meningitidis

3g3z, resolution 2.10Å

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