3g9v: Difference between revisions

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{{Seed}}
[[Image:3g9v.png|left|200px]]


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==Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22==
The line below this paragraph, containing "STRUCTURE_3g9v", creates the "Structure Box" on the page.
<StructureSection load='3g9v' size='340' side='right'caption='[[3g9v]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3g9v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G9V FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.756&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g9v OCA], [https://pdbe.org/3g9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g9v RCSB], [https://www.ebi.ac.uk/pdbsum/3g9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g9v ProSAT]</span></td></tr>
{{STRUCTURE_3g9v|  PDB=3g9v  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/I22R2_HUMAN I22R2_HUMAN] Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.<ref>PMID:11390454</ref> <ref>PMID:11390453</ref> <ref>PMID:11481447</ref>  Isoform 1 may play a role in establishing and maintaining successful pregnancy.<ref>PMID:11390454</ref> <ref>PMID:11390453</ref> <ref>PMID:11481447</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/3g9v_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g9v ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Interleukin-22 (IL-22) plays an important role in the regulation of immune and inflammatory responses in mammals. The IL-22 binding protein (IL-22BP), a soluble receptor that specifically binds IL-22, prevents the IL-22/interleukin-22 receptor 1 (IL-22R1)/interleukin-10 receptor 2 (IL-10R2) complex assembly and blocks IL-22 biological activity. Here we present the crystal structure of the IL-22/IL-22BP complex at 2.75 A resolution. The structure reveals IL-22BP residues critical for IL-22 binding, which were confirmed by site-directed mutagenesis and functional studies. Comparison of IL-22/IL-22BP and IL-22/IL-22R1 crystal structures shows that both receptors display an overlapping IL-22 binding surface, which is consistent with the inhibitory role played by IL-22 binding protein.


===Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22===
Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22.,de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I FEBS Lett. 2009 Apr 2;583(7):1072-7. Epub 2009 Mar 11. PMID:19285080<ref>PMID:19285080</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3g9v" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19285080}}, adds the Publication Abstract to the page
*[[Interleukin 3D structures|Interleukin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19285080 is the PubMed ID number.
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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== References ==
{{ABSTRACT_PUBMED_19285080}}
<references/>
 
__TOC__
==About this Structure==
</StructureSection>
3G9V is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G9V OCA].
 
==Reference==
<ref group="xtra">PMID:19285080</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bleicher, L.]]
[[Category: Large Structures]]
[[Category: Colau, D.]]
[[Category: Bleicher L]]
[[Category: Moura, P R.de.]]
[[Category: Colau D]]
[[Category: Polikarpov, I.]]
[[Category: Polikarpov I]]
[[Category: Renauld, J C.]]
[[Category: Renauld J-C]]
[[Category: Watanabe, L.]]
[[Category: Watanabe L]]
[[Category: Cytokine]]
[[Category: De Moura PR]]
[[Category: Cytokine receptor]]
[[Category: Cytokine/cytokine receptor complex]]
[[Category: Glycoprotein]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Secreted]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  6 10:20:37 2009''

Latest revision as of 09:11, 30 October 2024

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22

3g9v, resolution 2.76Å

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