3hb4: Difference between revisions
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New page: '''Unreleased structure''' The entry 3hb4 is ON HOLD Authors: Mazumdar, M., Fournier, D., Zhu, D.-W., Cadot, C., Poirier, D., Lin, S.-X. Description: 17beta-hydroxysteroid dehydrogenas... |
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==17beta-hydroxysteroid dehydrogenase type1 complexed with E2B== | |||
<StructureSection load='3hb4' size='340' side='right'caption='[[3hb4]], [[Resolution|resolution]] 2.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3hb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HB4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E2B:3-{[(9BETA,14BETA,16ALPHA,17ALPHA)-3,17-DIHYDROXYESTRA-1,3,5(10)-TRIEN-16-YL]METHYL}BENZAMIDE'>E2B</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hb4 OCA], [https://pdbe.org/3hb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hb4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hb4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/3hb4_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hb4 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cadot C]] | |||
[[Category: Fournier D]] | |||
[[Category: Lin S-X]] | |||
[[Category: Mazumdar M]] | |||
[[Category: Poirier D]] | |||
[[Category: Zhu D-W]] | |||
Latest revision as of 09:59, 21 February 2024
17beta-hydroxysteroid dehydrogenase type1 complexed with E2B
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