2wbk: Difference between revisions

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{{Seed}}
[[Image:2wbk.png|left|200px]]


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==Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis==
The line below this paragraph, containing "STRUCTURE_2wbk", creates the "Structure Box" on the page.
<StructureSection load='2wbk' size='340' side='right'caption='[[2wbk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2wbk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M2F:2,4-DINITROPHENYL+2-DEOXY-2-FLUORO-BETA-D-MANNOPYRANOSIDE'>M2F</scene></td></tr>
{{STRUCTURE_2wbk|  PDB=2wbk  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbk OCA], [https://pdbe.org/2wbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbk RCSB], [https://www.ebi.ac.uk/pdbsum/2wbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8AAK6_BACTN Q8AAK6_BACTN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wbk ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Michaelis complex of the beta-mannosidase Man2A shows distortion to a (1)S(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.


===STRUCTURE OF THE MICHAELIS COMPLEX OF BETA-MANNOSIDASE, MAN2A, PROVIDES INSIGHT INTO THE CONFORMATIONAL ITINERARY OF MANNOSIDE HYDROLYSIS===
Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.,Offen WA, Zechel DL, Withers SG, Gilbert HJ, Davies GJ Chem Commun (Camb). 2009 May 14;(18):2484-6. Epub 2009 Apr 6. PMID:19532864<ref>PMID:19532864</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2wbk" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19532864}}, adds the Publication Abstract to the page
*[[Mannosidase 3D structures|Mannosidase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19532864 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19532864}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Bacteroides thetaiotaomicron VPI-5482]]
2WBK is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBK OCA].
[[Category: Large Structures]]
 
[[Category: Davies GJ]]
==Reference==
[[Category: Gilbert HJ]]
<ref group="xtra">PMID:19532864</ref><references group="xtra"/>
[[Category: Offen WA]]
[[Category: Bacteroides thetaiotaomicron]]
[[Category: Withers SG]]
[[Category: Beta-mannosidase]]
[[Category: Zechel DL]]
[[Category: Davies, G J.]]
[[Category: Gilbert, H J.]]
[[Category: Offen, W A.]]
[[Category: Withers, S G.]]
[[Category: Zechel, D L.]]
[[Category: Beta-mannoside]]
[[Category: Conformational itinerary]]
[[Category: Glycoside hydrolase]]
[[Category: Hydrolase]]
[[Category: Mannosidase]]
[[Category: Michaelis complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  1 09:16:54 2009''

Latest revision as of 15:50, 13 December 2023

Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

2wbk, resolution 2.10Å

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