3hnb: Difference between revisions

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{{Seed}}
[[Image:3hnb.png|left|200px]]
[[Image:3hnb.png|left|200px]]


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{{STRUCTURE_3hnb|  PDB=3hnb  |  SCENE=  }}  
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===Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor===
===Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor===


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{{ABSTRACT_PUBMED_20089867}}
{{ABSTRACT_PUBMED_20089867}}


==Disease==
==About this Structure==
Known disease associated with this structure: Hemophilia A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=306700 306700]]
[[3hnb]] is a 1 chain structure of [[Factor VIII]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HNB OCA].


==About this Structure==
==See Also==
3HNB is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HNB OCA].
*[[Factor VIII|Factor VIII]]


==Reference==
==Reference==
<ref group="xtra">PMID:20089867</ref><references group="xtra"/>
<ref group="xtra">PMID:020089867</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Liu, Z.]]
[[Category: Liu, Z.]]
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[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Small molecule inhibitor/blood clotting]]
[[Category: Small molecule inhibitor/blood clotting]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:59:07 2010''

Revision as of 14:48, 26 July 2012

File:3hnb.png

Template:STRUCTURE 3hnb

Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor

Template:ABSTRACT PUBMED 20089867

About this Structure

3hnb is a 1 chain structure of Factor VIII with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J Biol Chem. 2010 Mar 19;285(12):8824-9. Epub 2010 Jan 20. PMID:20089867 doi:10.1074/jbc.M109.080168

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