Cadherin: Difference between revisions
New page: left|200px|thumb|Crystal Structure of Cadherin, [[1q1p]] {{STRUCTURE_1q1p| PDB=1q1p | SIZE=300| SCENE= |right|CAPTION=Cadherin, 1q1p }} '''Cadherins''' (CDH) are ... |
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=== CDH encoded by CDH1 === | |||
[[1q1p]] – mCDH1 - mouse<br /> | |||
=== CDH encoded by CDH5 === | |||
[[2koh]] – mCDH5+PAR3-PDZ3<br /> | |||
=== CDH encoded by CDH6 === | |||
[[3lnd]] – mCDH6 EC12 (mutant)<br /> | |||
=== CDH encoded by CDH8 === | |||
[[1zxk]] – mCDH8 EC1<br /> | |||
[[2a62]] - mCDH8 EC1+EC2+EC3<br /> | |||
=== CDH encoded by CDH11 === | |||
[[2a4c]], [[2a4e]] – mCDH11 EC1<br /> | |||
=== CDH encoded by CDH20 === | |||
[[1zvn]] – cCDH20 EC1 – chicken<br /> | |||
2yqg – hDes-CDH EC1 | === CDH encoded by CDH23 === | ||
[[3mvs]], [[2whv]] – mCDH23 N-terminal<br /> | |||
[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br /> | |||
[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br /> | |||
=== C-CDH “classical” === | |||
[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br /> | |||
[[1q5b]], [[1q5c]] – C-CDH model into desmosome – electron tomography<br /> | |||
=== E-CDH epithelial === | |||
[[1ff5]] – mE-CDH double domain<br /> | |||
[[1edh]] - mE-CDH EC1+EC2+Ca<br /> | |||
[[1suh]] – mE-CDH N-terminal - NMR<br /> | |||
[[3l6x]], [[3l6y]], [[1i7x]], [[1i7w]] – mE-CDH+catenin<br /> | |||
[[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]] – mE-CDH EC12 (mutant)<br /> | |||
[[3ifq]] – hE-CDH EC1+EC2+EC3 <br /> | |||
[[2o72]] - hE-CDH EC1+EC2<br /> | |||
[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br /> | |||
[[2qvf]] – mE-CDH1 CDH2<br /> | |||
[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br /> | |||
[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br /> | |||
=== T-CDH membrane bound === | |||
[[3k5r]] – mT-CDH EC1+EC2<br /> | |||
[[3k5s]] - cT-CDH EC1+EC2 <br /> | |||
[[3k6d]] - XlT-CDH EC1 <br /> | |||
[[3k6f]] - mT-CDH EC1<br /> | |||
[[3k6i]] - cT-CDH EC1<br /> | |||
[[2v37]] – hT-CDH N-terminal - NMR<br /> | |||
=== N-CDH neuronal === | |||
[[1nch]], [[1nci]] – mN-CDH<br /> | |||
[[1ncg]] – mN-CDH (mutant)<br /> | |||
[[2qvi]] – mN-CDH EC12<br /> | |||
[[1ncj]] – mN-CDH two domains<br /> | |||
=== Protocadherin === | |||
[[2yst]] – hProt-CDH7 EC3 – NMR<br /> | |||
=== Desmoglein === | |||
[[2yqg]] – hDes-CDH EC1<br /> | |||
Revision as of 11:37, 16 September 2010
Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), T-CDH bound to membrane, N-CDH (neurons). The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, i.e. the crystal structure of Cadherin (1q1p). Calcium ions is shown as a space filling objects.
3D Structures of Cadherin
CDH encoded by CDH1
1q1p – mCDH1 - mouse
CDH encoded by CDH5
2koh – mCDH5+PAR3-PDZ3
CDH encoded by CDH6
3lnd – mCDH6 EC12 (mutant)
CDH encoded by CDH8
1zxk – mCDH8 EC1
2a62 - mCDH8 EC1+EC2+EC3
CDH encoded by CDH11
CDH encoded by CDH20
1zvn – cCDH20 EC1 – chicken
CDH encoded by CDH23
3mvs, 2whv – mCDH23 N-terminal
2kbr – hCDH23 peptide+harmonin – NMR - human
2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR
C-CDH “classical”
1l3w – XlC-CDH ectodomain - Xenopus laevis
1q5b, 1q5c – C-CDH model into desmosome – electron tomography
E-CDH epithelial
1ff5 – mE-CDH double domain
1edh - mE-CDH EC1+EC2+Ca
1suh – mE-CDH N-terminal - NMR
3l6x, 3l6y, 1i7x, 1i7w – mE-CDH+catenin
3lne, 3lnf, 3lng, 3lnh, 3lni – mE-CDH EC12 (mutant)
3ifq – hE-CDH EC1+EC2+EC3
2o72 - hE-CDH EC1+EC2
3ff7, 3ff8 - hE-CDH EC1+EC2+EC3+NK cell receptor
2qvf – mE-CDH1 CDH2
2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)
1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes
T-CDH membrane bound
3k5r – mT-CDH EC1+EC2
3k5s - cT-CDH EC1+EC2
3k6d - XlT-CDH EC1
3k6f - mT-CDH EC1
3k6i - cT-CDH EC1
2v37 – hT-CDH N-terminal - NMR
N-CDH neuronal
1nch, 1nci – mN-CDH
1ncg – mN-CDH (mutant)
2qvi – mN-CDH EC12
1ncj – mN-CDH two domains
Protocadherin
2yst – hProt-CDH7 EC3 – NMR
Desmoglein
2yqg – hDes-CDH EC1
