2ilm: Difference between revisions

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[[Image:2ilm.png|left|200px]]
[[Image:2ilm.png|left|200px]]


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{{STRUCTURE_2ilm|  PDB=2ilm  |  SCENE=  }}  
{{STRUCTURE_2ilm|  PDB=2ilm  |  SCENE=  }}  


===Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer===
===Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer===


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{{ABSTRACT_PUBMED_18611856}}
{{ABSTRACT_PUBMED_18611856}}


==About this Structure==
==About this Structure==
[[2ilm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ILM OCA].  
[[2ilm]] is a 2 chain structure of [[Factor inhibiting HIF]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ILM OCA].  
 
==See Also==
*[[Factor inhibiting HIF|Factor inhibiting HIF]]


==Reference==
==Reference==
<ref group="xtra">PMID:18611856</ref><ref group="xtra">PMID:12446723</ref><ref group="xtra">PMID:15913349</ref><references group="xtra"/>
<ref group="xtra">PMID:018611856</ref><ref group="xtra">PMID:012446723</ref><ref group="xtra">PMID:015913349</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptide-aspartate beta-dioxygenase]]
[[Category: Peptide-aspartate beta-dioxygenase]]

Revision as of 16:34, 26 July 2012

File:2ilm.png

Template:STRUCTURE 2ilm

Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer

Template:ABSTRACT PUBMED 18611856

About this Structure

2ilm is a 2 chain structure of Factor inhibiting HIF with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J Biol Chem. 2008 Sep 19;283(38):25971-8. Epub 2008 Jul 8. PMID:18611856 doi:10.1074/jbc.M804999200
  2. Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. J Biol Chem. 2003 Jan 17;278(3):1802-6. Epub 2002 Nov 21. PMID:12446723 doi:https://dx.doi.org/10.1074/jbc.C200644200
  3. McDonough MA, McNeill LA, Tilliet M, Papamicael CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. Selective inhibition of factor inhibiting hypoxia-inducible factor. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. PMID:15913349 doi:10.1021/ja050841b

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