Factor VIII: Difference between revisions
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[[Factor VIII]] (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for [[Factor IX|factor IXa]]. The images at the left and at the right correspond to one representative FVIII, ''i.e.'' the crystal structure of human Factor VIII ([[2r7e]]). | [[Factor VIII]] (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for [[Factor IX|factor IXa]]. The images at the left and at the right correspond to one representative FVIII, ''i.e.'' the crystal structure of human Factor VIII ([[2r7e]]). | ||
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===RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII=== | |||
The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the | |||
<scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.--> | |||
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Revision as of 12:12, 3 June 2012
Factor VIII (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for factor IXa. The images at the left and at the right correspond to one representative FVIII, i.e. the crystal structure of human Factor VIII (2r7e).
3D Structures of Factor VIII
2r7e, 3cdz – hFVIII – human
3hnb, 3hny, 3hob – hFVIII light chain C2 domain
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
