GTP-binding protein

File:2nzj.png

Crystal Structure of GTP-binding protein complex with nucleotide 2nzj

GTP-binding proteins or G proteins are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins and small GTPases. The images at the left and at the right correspond to one representative G protein, i.e. the crystal structure of human GTP-binding protein complex with nucleotide (2nzj).

3D Structures of GTP-binding protein

GTP-binding protein

3r7w – yGtr1 + Gtr2 – yeast
2dpx – hRad GTPase domain - human
3kxk, 3kxl – SsHflx (mutant) - Sulfolobus solfataricus
2qtf – SsHflx
1ega – EcERA – Escherichia coli
2dyk – TtEngA N terminal – Thermus thermophilus - Cryo EM
3cb4 - EcLepA
2ywe – AaLepA
1sul – BsYsxC - Bacillus subtilis
2dwq – TtYchF
1udx – TtObg
1wxq – GBP – Pyrococcus horikoshii
1ni3 – YchF – Schizosaccharomyces pombe

GTP-binding protein complex with nucleotide

2nzj – hRem1 + GDP
3cbq – hRem2 + GDP
2cjw, 2ht6, 2g3y – hGem G domain + GDP
2ohf – hOla1 + AMP-PCP
1xtq – hRheB + GDP
1xts - hRheB + GTP
1xtr - hRheB + GPPNHP
3kxi, 2qth – SsHflx + GDP
3ieu – EcERA + GDP
3iev – AaERA + RNA + Mg-GNP – Aquifex aeolicus
1x1l – TtERA + RNA – Cryo EM
2ywf – AaLepA + GMP-PNP
2ywg - AaLepA + GTP
2ywh - AaLepA + GDP
1yzn – yPt1 + GPPNHP
1ky2 – yPt7 + GPPNHP
1ky3 – yPt7 + GDP
1ek0 – yPt51 + GPPNHP
2hjg – BsEngA + GDP
1svi – BsYsxC + GDP
1svw – BsYsxC + GMPPNP
1lnz – BsObg + GTP
2dby – TtYchF + GDP
1wf3 – Tt1341 + GNP
2gao - hSar1A + GDP
2fa9 – ChSar1B (mutant) + GDP – Chinese hamster
2fmx - ChSar1B + GDP
1byu – Ran + GDP - dog

GTP-binding protein complex with protein

1ees – hCdc42 + MapK3 peptide - NMR
1x18 – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM
3deg – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM
3cue – yPt1 + transport protein subunits
2bcg, 1ukv - yPt1 + secretory pathway GDP-dissociation inhibitor
3cpj – yPt31 + Rab GDP-dissociation inhibitor
1m2o – ySar1 + protein transport protein sec23

Ras-related GTP-binding protein

3llu – hC nucleotide-binding domain

Ras-related GTP-binding protein complex with nucleotide

2l0x – Rheb + GDP – rat
2gjs – hRad1 + GDP
2gf0 – hDiRas1 + GDP
2erx – hDiRas2 + Pi + GDP
1x3s – hRab-18 + GPPNHP
1yu9 - hRab-4A + GPPNHP
2atx – hTc10 + GPPNHP
1g16 – ySec4 + GDP
1g17 - ySec4 + GIP

Ras-related GTP-binding protein complex with protein

3kuc – hRap-1A + proto oncogene Ser/Thr protein kinase
3cf6 - hRap-1A + Rap guanine nucleotide exchange factor 4
3brw - hRap-1B + Rap GTPase-activating protein
1z0k – hRab-4 + rabenosyn-5

Interferon-induced GTP-binding protein

3ljb – hMx1 stalk region

Rho-related GTP-binding protein

2j1l – hRhoD

Ras-related GTP-binding protein complex with nucleotide

2cls – hRho6 + GTP
2fv8 - hRhoB + GDP
2gcn – hRhoC + GDP
2gco – hRhoC + GPPNHP
1z2c - hRhoC (mutant) + GMPPNP
2gcp – hRhoC + GSP
1m7b - hRhoE + GTP
1gwn - RhoE + GTP - mouse
1a4r - hCdc42 (mutant) + GDP
1an0 - hCdc42 + GDP

Ras-related GTP-binding protein complex with protein

2v55 – hRhoE + Rho-associated protein kinase
3q3j – hRho6 + plexin-A2 nucleotide-binding domain
2rex – hRho6 + plexin-B1
1cc0 – hRhoA + GDP-dissociation inhibitor + GDP
3a58 – yRho1 (mutant) + exocyst complex component Sec3
1gzs – Cdc42 + guanine nucleotide exchange factor – Salmonella typhimurium
1ki1 – hCdc42 + intersectin long form
1ees – hCdc42 + MapK3 peptide - NMR
1doa - hCdc42 + GDP-dissociation inhibitor

Rac-like GTP-binding protein

2wbl – AtArac2 + Rho of plant guanine nucleotide exchange factor 8 – Arabidopsis thaliana
3bwd – AtArac6
2nty – AtArac5 + prone8
2j0v – AtArac7 (mutant)

Rab-related GTP-binding protein

2ys8 – hRabJ DNAJ domain – NMR

Flagella-associated GTP-binding protein

2px0 – BsFlhF + GMP-PNP
2px3 – BsFlhF + GTP

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Wayne Decatur, Joel L. Sussman, Jaime Prilusky, Michal Harel