3juh: Difference between revisions

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[[Image:3juh.png|left|200px]]
[[Image:3juh.png|left|200px]]


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{{STRUCTURE_3juh|  PDB=3juh  |  SCENE=  }}  
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===Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity===
===Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity===


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==See Also==
==See Also==
*[[Casein kinase]]
*[[Casein kinase|Casein kinase]]


==Reference==
==Reference==

Revision as of 08:58, 27 July 2012

File:3juh.png

Template:STRUCTURE 3juh

Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity

Template:ABSTRACT PUBMED 15740749

About this Structure

3juh is a 2 chain structure of Casein kinase with sequence from Homo sapiens. This structure supersedes the now removed PDB entries and 1ymi. Full crystallographic information is available from OCA.

See Also

Reference

  1. Yde CW, Ermakova I, Issinger OG, Niefind K. Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate. J Mol Biol. 2005 Mar 25;347(2):399-414. Epub 2005 Jan 18. PMID:15740749 doi:https://dx.doi.org/10.1016/j.jmb.2005.01.003
  2. Raaf J, Brunstein E, Issinger OG, Niefind K. The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules. Chem Biol. 2008 Feb;15(2):111-7. PMID:18291315 doi:https://dx.doi.org/10.1016/j.chembiol.2007.12.012
  3. Niefind K, Issinger OG. Conformational plasticity of the catalytic subunit of protein kinase CK2 and its consequences for regulation and drug design. Biochim Biophys Acta. 2010 Mar;1804(3):484-92. Epub 2009 Sep 28. PMID:19796713 doi:10.1016/j.bbapap.2009.09.022
  4. Niefind K, Raaf J, Issinger OG. Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights. Cell Mol Life Sci. 2009 Jun;66(11-12):1800-16. PMID:19387553 doi:10.1007/s00018-009-9149-8

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