MDM4: Difference between revisions
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Michal Harel (talk | contribs) New page: {{STRUCTURE_3dab| PDB=3dab | SIZE=400| SCENE=1 |right|CAPTION=Human MDM4 complex with p53 transactivation domain , 3dab }} '''MDM4''' is a 490 amino acid protein containing a RING f... |
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{{ | {{STRUCTURE_3dac| PDB=3dac | SIZE=400| SCENE=1 |right|CAPTION=Human MDM4 complex with p53 transactivation domain , [[3dac]] }} | ||
'''MDM4''' is a 490 amino acid protein containing a RING finger domain and a nuclear localization signal. MDM4 interacts with protein MDM2. Both of these proteins show structure similarity and contain a p53-binding domain in their N terminal. | '''MDM4''' is a 490 amino acid protein containing a RING finger domain and a nuclear localization signal. MDM4 interacts with protein MDM2. Both of these proteins show structure similarity and contain a p53-binding domain in their N terminal. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
== 3D Structures of MDM4 == | == 3D Structures of MDM4 == | ||
2cr8 – hMDM4 ZF-RNBP domain – NMR | [[2cr8]] – hMDM4 ZF-RNBP domain – NMR<br /> | ||
3dab – hMDM4 + p53 transactivation domain | [[3dab]] – hMDM4 + p53 transactivation domain<br /> | ||
3fdo, 3jzo, 3jzp, 3jzq, 3jzr, 3jzs – hMDM4 p53-binding domain + peptide | [[3fdo]], [[3jzo]], [[3jzp]], [[3jzq]], [[3jzr]], [[3jzs]] – hMDM4 p53-binding domain + peptide<br /> | ||
3lbj - hMDM4 p53-binding domain + inhibitor | [[3lbj]] - hMDM4 p53-binding domain + inhibitor<br /> | ||
3dac – hMDM4 (mutant) + p53 transactivation domain | [[3dac]] – hMDM4 (mutant) + p53 transactivation domain<br /> | ||
2vyr – hMDM4 N terminal + antibody | [[2vyr]] – hMDM4 N terminal + antibody<br /> | ||
3fe7, 3fea, 3eqy - hMDM4 N terminal (mutant) + peptide | [[3fe7]], [[3fea]], [[3eqy]] - hMDM4 N terminal (mutant) + peptide<br /> | ||
2vje, 2vjf – hMDM2 residues 383-446 + hMDM4 residues 428-490 | [[2vje]], [[2vjf]] – hMDM2 residues 383-446 + hMDM4 residues 428-490<br /> | ||
